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Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds.
Mar Biotechnol (NY). 2015 Oct; 17(5):624-32.MB

Abstract

In the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC50 values ranging from 18.57 to 1.86 μM and could be considered as low-toxicity antifouling compounds since their LC50/EC50 ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211(™) in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang KL
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Xu Y
No affiliation info available
Lu L
No affiliation info available
Li Y
No affiliation info available
Han Z
No affiliation info available
Zhang J
No affiliation info available
Shao CL
No affiliation info available
Wang CY
No affiliation info available
Qian PY
No affiliation info available

MeSH

AnimalsBiofoulingBiological ProductsBryozoaLarvaThiazolesThoracica

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26239187

Citation

Wang, Kai-Ling, et al. "Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds." Marine Biotechnology (New York, N.Y.), vol. 17, no. 5, 2015, pp. 624-32.
Wang KL, Xu Y, Lu L, et al. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Mar Biotechnol (NY). 2015;17(5):624-32.
Wang, K. L., Xu, Y., Lu, L., Li, Y., Han, Z., Zhang, J., Shao, C. L., Wang, C. Y., & Qian, P. Y. (2015). Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Marine Biotechnology (New York, N.Y.), 17(5), 624-32. https://doi.org/10.1007/s10126-015-9656-6
Wang KL, et al. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Mar Biotechnol (NY). 2015;17(5):624-32. PubMed PMID: 26239187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. AU - Wang,Kai-Ling, AU - Xu,Ying, AU - Lu,Liang, AU - Li,Yongxin, AU - Han,Zhuang, AU - Zhang,Jun, AU - Shao,Chang-Lun, AU - Wang,Chang-Yun, AU - Qian,Pei-Yuan, Y1 - 2015/08/04/ PY - 2014/11/23/received PY - 2015/05/27/accepted PY - 2015/8/5/entrez PY - 2015/8/5/pubmed PY - 2016/5/19/medline SP - 624 EP - 32 JF - Marine biotechnology (New York, N.Y.) JO - Mar Biotechnol (NY) VL - 17 IS - 5 N2 - In the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC50 values ranging from 18.57 to 1.86 μM and could be considered as low-toxicity antifouling compounds since their LC50/EC50 ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211(™) in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds. SN - 1436-2236 UR - https://www.unboundmedicine.com/medline/citation/26239187/Low_Toxicity_Diindol_3_ylmethanes_as_Potent_Antifouling_Compounds_ DB - PRIME DP - Unbound Medicine ER -