A Family with Axenfeld-Rieger Syndrome: Report of the Clinical and Genetic Findings.Korean J Ophthalmol. 2015 Aug; 29(4):249-55.KJ
To describe clinical findings in a Korean family with Axenfeld-Rieger syndrome.
A retrospective review of clinical data about patients with diagnosed Axenfeld-Rieger syndrome. Five affected members of the family underwent a complete ophthalmologic examination. We screened the forkhead box C1 gene and the pituitary homeobox 2 gene in patients. Peripheral blood leukocytes and buccal mucosal epithelial cells were obtained from seven members of a family with Axenfeld-Rieger syndrome. DNA was extracted and amplified by polymerase chain reaction, followed by direct sequencing.
The affected members showed iris hypoplasia, iridocorneal adhesions, posterior embryotoxon, and advanced glaucoma in three generation. None had systemic anomalies. Two mutations including c.1362_1364insCGG and c.1142_1144insGGC were identified in forkhead box C1 in four affected family members.
This study may help to understand clinical findings and prognosis for patients with Axenfeld-Rieger syndrome.