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Update on Biomarkers for the Detection of Endometriosis.
Biomed Res Int. 2015; 2015:130854.BR

Abstract

Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7-11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.

Authors+Show Affiliations

Department of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium.Departments of Obstetrics and Gynecology and Clinical Investigation, Madigan Healthcare System, Tacoma, WA 98431, USA.Department of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium.Department of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium ; Division of Reproductive Biology, Institute of Primate Research, Karen, Nairobi 00 100, Kenya.Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA 94015, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26240814

Citation

Fassbender, Amelie, et al. "Update On Biomarkers for the Detection of Endometriosis." BioMed Research International, vol. 2015, 2015, p. 130854.
Fassbender A, Burney RO, O DF, et al. Update on Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015;2015:130854.
Fassbender, A., Burney, R. O., O, D. F., D'Hooghe, T., & Giudice, L. (2015). Update on Biomarkers for the Detection of Endometriosis. BioMed Research International, 2015, 130854. https://doi.org/10.1155/2015/130854
Fassbender A, et al. Update On Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015;2015:130854. PubMed PMID: 26240814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on Biomarkers for the Detection of Endometriosis. AU - Fassbender,Amelie, AU - Burney,Richard O, AU - O,Dorien F, AU - D'Hooghe,Thomas, AU - Giudice,Linda, Y1 - 2015/07/09/ PY - 2014/10/31/received PY - 2015/01/14/accepted PY - 2015/8/5/entrez PY - 2015/8/5/pubmed PY - 2016/4/14/medline SP - 130854 EP - 130854 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7-11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26240814/Update_on_Biomarkers_for_the_Detection_of_Endometriosis_ L2 - https://dx.doi.org/10.1155/2015/130854 DB - PRIME DP - Unbound Medicine ER -