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Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris.

Abstract

BACKGROUND

A relationship between acne vulgaris (AV) and the masculinized (lower) second-to-fourth digit (2D:4D) ratio in females was demonstrated in our previous study. Development of the digits and the sebaceous glands both occur during the same gestational period; therefore, the association between the 2D:4D ratios and AV may result from the effects of the prenatal endocrine environment on the sebaceous glands.

OBJECTIVE

The aim of this study was to evaluate the relationship between the 2D:4D ratio and sebum levels in the skin of females with AV.

METHODS

In total, 215 female AV patients and 92 healthy controls, aged 18-35 years, were enrolled in this study. Finger-length measurements were made using a digital Vernier caliper, and the sebum levels of five facial areas were measured using a Sebumeter SM 815. Acne severity was assessed using the International Consensus Conference on Acne Classification System.

RESULTS

The 2D:4D ratios of the AV patients were significantly lower than those of the controls, for both hands. The mean sebum levels in the T-zone, U-zone and whole face were significantly higher for AV patients compared with controls. The 2D:4D ratio in the left hand showed significant negative correlations with the sebum levels in the U-zone; however, no association was found between the 2D:4D ratios and sebum levels in the T-zone and whole face. While acne severity was positively correlated with skin sebum levels, no correlation between acne severity and 2D:4D ratios was observed.

CONCLUSION

This study provides preliminary evidence regarding the association between lower 2D:4D ratios and higher rates of sebum secretion in the U-zone for females with AV. The 2D:4D ratio might be a predictor of sebum levels, as well as acne development, in females.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, School of Medicine, Selcuk University, 42075, Konya, Turkey. bilgicozlem@yahoo.com.

    ,

    Department of Dermatology, School of Medicine, Selcuk University, 42075, Konya, Turkey.

    ,

    Department of Dermatology, School of Medicine, Selcuk University, 42075, Konya, Turkey.

    Department of Dermatology, School of Medicine, Selcuk University, 42075, Konya, Turkey.

    Source

    MeSH

    Acne Vulgaris
    Adolescent
    Adult
    Case-Control Studies
    Disease Progression
    Female
    Fingers
    Humans
    Reference Values
    Sebum
    Skin
    Statistics, Nonparametric
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26242229

    Citation

    Bilgiç, Özlem, et al. "Investigation of the Association of the Second-to-Fourth Digit Ratio With Skin Sebum Levels in Females With Acne Vulgaris." American Journal of Clinical Dermatology, vol. 16, no. 6, 2015, pp. 559-64.
    Bilgiç Ö, Altınyazar C, Hıra H, et al. Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris. Am J Clin Dermatol. 2015;16(6):559-64.
    Bilgiç, Ö., Altınyazar, C., Hıra, H., & Doğdu, M. (2015). Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris. American Journal of Clinical Dermatology, 16(6), pp. 559-64. doi:10.1007/s40257-015-0147-3.
    Bilgiç Ö, et al. Investigation of the Association of the Second-to-Fourth Digit Ratio With Skin Sebum Levels in Females With Acne Vulgaris. Am J Clin Dermatol. 2015;16(6):559-64. PubMed PMID: 26242229.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris. AU - Bilgiç,Özlem, AU - Altınyazar,Cevdet, AU - Hıra,Hüseyin, AU - Doğdu,Murat, PY - 2015/8/6/entrez PY - 2015/8/6/pubmed PY - 2016/9/8/medline SP - 559 EP - 64 JF - American journal of clinical dermatology JO - Am J Clin Dermatol VL - 16 IS - 6 N2 - BACKGROUND: A relationship between acne vulgaris (AV) and the masculinized (lower) second-to-fourth digit (2D:4D) ratio in females was demonstrated in our previous study. Development of the digits and the sebaceous glands both occur during the same gestational period; therefore, the association between the 2D:4D ratios and AV may result from the effects of the prenatal endocrine environment on the sebaceous glands. OBJECTIVE: The aim of this study was to evaluate the relationship between the 2D:4D ratio and sebum levels in the skin of females with AV. METHODS: In total, 215 female AV patients and 92 healthy controls, aged 18-35 years, were enrolled in this study. Finger-length measurements were made using a digital Vernier caliper, and the sebum levels of five facial areas were measured using a Sebumeter SM 815. Acne severity was assessed using the International Consensus Conference on Acne Classification System. RESULTS: The 2D:4D ratios of the AV patients were significantly lower than those of the controls, for both hands. The mean sebum levels in the T-zone, U-zone and whole face were significantly higher for AV patients compared with controls. The 2D:4D ratio in the left hand showed significant negative correlations with the sebum levels in the U-zone; however, no association was found between the 2D:4D ratios and sebum levels in the T-zone and whole face. While acne severity was positively correlated with skin sebum levels, no correlation between acne severity and 2D:4D ratios was observed. CONCLUSION: This study provides preliminary evidence regarding the association between lower 2D:4D ratios and higher rates of sebum secretion in the U-zone for females with AV. The 2D:4D ratio might be a predictor of sebum levels, as well as acne development, in females. SN - 1179-1888 UR - https://www.unboundmedicine.com/medline/citation/26242229/Investigation_of_the_Association_of_the_Second_to_Fourth_Digit_Ratio_with_Skin_Sebum_Levels_in_Females_with_Acne_Vulgaris_ L2 - https://dx.doi.org/10.1007/s40257-015-0147-3 DB - PRIME DP - Unbound Medicine ER -