Tags

Type your tag names separated by a space and hit enter

Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI.
Eur J Nucl Med Mol Imaging. 2016 Jan; 43(1):92-102.EJ

Abstract

PURPOSE

To evaluate the accuracy of integrated (18)F-FDG PET/MR imaging for locoregional tumour evaluation compared to (18)F-FDG PET/CT and MR imaging in initial tumour and recurrence diagnosis in histopathologically confirmed head and neck squamous cell carcinoma (HNSCC).

METHODS

(18)F-FDG PET/CT and integrated (18)F-FDG PET/MR imaging were performed for initial tumour staging or recurrence diagnosis in 25 patients with HNSCC. MR, fused (18)F-FDG PET/CT and fused (18)F-FDG PET/MR images were analysed by two independent readers in separate sessions in random order. In initial tumour staging, T and N staging was performed while individual lesions were analysed in patients with suspected cancer recurrence. In T and N staging, histopathological results after tumour resection served as the reference standard while histopathological sampling as well as cross-sectional and clinical follow-up were accepted in cancer recurrence diagnosis. The diagnostic accuracy of each modality was calculated separately for T and N staging as well as for tumour recurrence, and compared using McNemar's test. Values of p <0.017 were considered statistically significant after Bonferroni correction.

RESULTS

In 12 patients undergoing (18)F-FDG PET/CT and (18)F-FDG PET/MR for initial tumour staging, T staging was accurate in 50 % with MRI, in 59 % with PET/CT and in 75 % with PET/MR while N staging was accurate in 75 % with MRI, in 77 % with PET/CT and in 71 % with PET/MR in relation to the reference standard. No significant differences were observed in T and N staging among the three modalities (p > 0.017). In 13 patients undergoing hybrid imaging for cancer recurrence diagnosis, diagnostic accuracy was 57 % with MRI and in 72 % with (18)F-FDG PET/CT and (18)F-FDG PET/MR, respectively. Again, no significant differences were found among the three modalities (p > 0.017).

CONCLUSION

In this initial study, no significant differences were found among (18)F-FDG PET/MR, (18)F-FDG PET/CT and MRI in local tumour staging and cancer recurrence diagnosis.

Authors+Show Affiliations

Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany. Benedikt.Schaarschmidt@med.uni-duesseldorf.de. Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, 45147, Essen, Germany. Benedikt.Schaarschmidt@med.uni-duesseldorf.de.Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.Medical Faculty, Department of Nuclear Medicine, University Duisburg-Essen, 45147, Essen, Germany.Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Essen, 45147, Essen, Germany.Medical Faculty, Department of Nuclear Medicine, University Duisburg-Essen, 45147, Essen, Germany.Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, 45147, Essen, Germany. Department of Neuroradiology, University Hospital Giessen, Marburg, Germany.Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, 45147, Essen, Germany.Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, 45147, Essen, Germany.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26243264

Citation

Schaarschmidt, Benedikt Michael, et al. "Locoregional Tumour Evaluation of Squamous Cell Carcinoma in the Head and Neck Area: a Comparison Between MRI, PET/CT and Integrated PET/MRI." European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 1, 2016, pp. 92-102.
Schaarschmidt BM, Heusch P, Buchbender C, et al. Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI. Eur J Nucl Med Mol Imaging. 2016;43(1):92-102.
Schaarschmidt, B. M., Heusch, P., Buchbender, C., Ruhlmann, M., Bergmann, C., Ruhlmann, V., Schlamann, M., Antoch, G., Forsting, M., & Wetter, A. (2016). Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI. European Journal of Nuclear Medicine and Molecular Imaging, 43(1), 92-102. https://doi.org/10.1007/s00259-015-3145-z
Schaarschmidt BM, et al. Locoregional Tumour Evaluation of Squamous Cell Carcinoma in the Head and Neck Area: a Comparison Between MRI, PET/CT and Integrated PET/MRI. Eur J Nucl Med Mol Imaging. 2016;43(1):92-102. PubMed PMID: 26243264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI. AU - Schaarschmidt,Benedikt Michael, AU - Heusch,Philipp, AU - Buchbender,Christian, AU - Ruhlmann,Marcus, AU - Bergmann,Christoph, AU - Ruhlmann,Verena, AU - Schlamann,Marc, AU - Antoch,Gerald, AU - Forsting,Michael, AU - Wetter,Axel, Y1 - 2015/08/06/ PY - 2015/03/06/received PY - 2015/07/14/accepted PY - 2015/8/6/entrez PY - 2015/8/6/pubmed PY - 2016/9/27/medline KW - HNSCC KW - Head and neck KW - MRI KW - PET/CT KW - PET/MR KW - PET/MRI SP - 92 EP - 102 JF - European journal of nuclear medicine and molecular imaging JO - Eur. J. Nucl. Med. Mol. Imaging VL - 43 IS - 1 N2 - PURPOSE: To evaluate the accuracy of integrated (18)F-FDG PET/MR imaging for locoregional tumour evaluation compared to (18)F-FDG PET/CT and MR imaging in initial tumour and recurrence diagnosis in histopathologically confirmed head and neck squamous cell carcinoma (HNSCC). METHODS: (18)F-FDG PET/CT and integrated (18)F-FDG PET/MR imaging were performed for initial tumour staging or recurrence diagnosis in 25 patients with HNSCC. MR, fused (18)F-FDG PET/CT and fused (18)F-FDG PET/MR images were analysed by two independent readers in separate sessions in random order. In initial tumour staging, T and N staging was performed while individual lesions were analysed in patients with suspected cancer recurrence. In T and N staging, histopathological results after tumour resection served as the reference standard while histopathological sampling as well as cross-sectional and clinical follow-up were accepted in cancer recurrence diagnosis. The diagnostic accuracy of each modality was calculated separately for T and N staging as well as for tumour recurrence, and compared using McNemar's test. Values of p <0.017 were considered statistically significant after Bonferroni correction. RESULTS: In 12 patients undergoing (18)F-FDG PET/CT and (18)F-FDG PET/MR for initial tumour staging, T staging was accurate in 50 % with MRI, in 59 % with PET/CT and in 75 % with PET/MR while N staging was accurate in 75 % with MRI, in 77 % with PET/CT and in 71 % with PET/MR in relation to the reference standard. No significant differences were observed in T and N staging among the three modalities (p > 0.017). In 13 patients undergoing hybrid imaging for cancer recurrence diagnosis, diagnostic accuracy was 57 % with MRI and in 72 % with (18)F-FDG PET/CT and (18)F-FDG PET/MR, respectively. Again, no significant differences were found among the three modalities (p > 0.017). CONCLUSION: In this initial study, no significant differences were found among (18)F-FDG PET/MR, (18)F-FDG PET/CT and MRI in local tumour staging and cancer recurrence diagnosis. SN - 1619-7089 UR - https://www.unboundmedicine.com/medline/citation/26243264/Locoregional_tumour_evaluation_of_squamous_cell_carcinoma_in_the_head_and_neck_area:_a_comparison_between_MRI_PET/CT_and_integrated_PET/MRI_ DB - PRIME DP - Unbound Medicine ER -