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Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study.
Mult Scler 2016; 22(5):685-93MS

Abstract

BACKGROUND

Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear.

OBJECTIVE

To evaluate the associations between cigarette smoking, alcohol use, and depression and anxiety in MS in a cross-Canada prospective study.

METHODS

From July 2010 to March 2011 we recruited consecutive MS patients from four MS clinics. At three visits over two years, clinical and demographic information was collected, and participants completed questionnaires regarding health behaviours and mental health.

RESULTS

Of 949 participants, 75.2% were women, with a mean age of 48.6 years; most had a relapsing-remitting course (72.4%). Alcohol dependence was associated with increased odds of anxiety (OR: 1.84; 95% CI: 1.32-2.58) and depression (OR: 1.53; 95% CI: 1.05-2.23) adjusting for age, sex, Expanded Disability Status Scale (EDSS), and smoking status. Smoking was associated with increased odds of anxiety (OR: 1.29; 95% CI: 1.02-1.63) and depression (OR: 1.37; 95% CI: 1.04-1.78) adjusting for age, sex, EDSS, and alcohol dependence. Alcohol dependence was associated with an increased incidence of depression but not anxiety. Depression was associated with an increased incidence of alcohol dependence.

CONCLUSION

Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those 'at risk'.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, University of British Columbia, Canada.Department of Neurology, Faculty of Medicine, University of British Columbia, Canada.Departments of Psychiatry, Psychology, & Neuroscience, Dalhousie University, Canada.Departments of Psychiatry & Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada.Department of Internal Medicine, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada.Department of Psychology, St. Francis Xavier University, Canada.Health Sciences Centre, College of Medicine, University of Manitoba, Canada rmarrie@hsc.mb.ca.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26245214

Citation

McKay, Kyla A., et al. "Adverse Health Behaviours Are Associated With Depression and Anxiety in Multiple Sclerosis: a Prospective Multisite Study." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 22, no. 5, 2016, pp. 685-93.
McKay KA, Tremlett H, Fisk JD, et al. Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study. Mult Scler. 2016;22(5):685-93.
McKay, K. A., Tremlett, H., Fisk, J. D., Patten, S. B., Fiest, K., Berrigan, L., & Marrie, R. A. (2016). Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study. Multiple Sclerosis (Houndmills, Basingstoke, England), 22(5), pp. 685-93. doi:10.1177/1352458515599073.
McKay KA, et al. Adverse Health Behaviours Are Associated With Depression and Anxiety in Multiple Sclerosis: a Prospective Multisite Study. Mult Scler. 2016;22(5):685-93. PubMed PMID: 26245214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study. AU - McKay,Kyla A, AU - Tremlett,Helen, AU - Fisk,John D, AU - Patten,Scott B, AU - Fiest,Kirsten, AU - Berrigan,Lindsay, AU - Marrie,Ruth Ann, AU - ,, Y1 - 2015/08/05/ PY - 2015/04/22/received PY - 2015/07/13/accepted PY - 2015/8/7/entrez PY - 2015/8/8/pubmed PY - 2016/12/23/medline KW - Multiple sclerosis KW - anxiety KW - cohort KW - depression KW - health behaviour SP - 685 EP - 93 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 22 IS - 5 N2 - BACKGROUND: Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear. OBJECTIVE: To evaluate the associations between cigarette smoking, alcohol use, and depression and anxiety in MS in a cross-Canada prospective study. METHODS: From July 2010 to March 2011 we recruited consecutive MS patients from four MS clinics. At three visits over two years, clinical and demographic information was collected, and participants completed questionnaires regarding health behaviours and mental health. RESULTS: Of 949 participants, 75.2% were women, with a mean age of 48.6 years; most had a relapsing-remitting course (72.4%). Alcohol dependence was associated with increased odds of anxiety (OR: 1.84; 95% CI: 1.32-2.58) and depression (OR: 1.53; 95% CI: 1.05-2.23) adjusting for age, sex, Expanded Disability Status Scale (EDSS), and smoking status. Smoking was associated with increased odds of anxiety (OR: 1.29; 95% CI: 1.02-1.63) and depression (OR: 1.37; 95% CI: 1.04-1.78) adjusting for age, sex, EDSS, and alcohol dependence. Alcohol dependence was associated with an increased incidence of depression but not anxiety. Depression was associated with an increased incidence of alcohol dependence. CONCLUSION: Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those 'at risk'. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/26245214/Adverse_health_behaviours_are_associated_with_depression_and_anxiety_in_multiple_sclerosis:_A_prospective_multisite_study_ L2 - http://journals.sagepub.com/doi/full/10.1177/1352458515599073?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -