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Neuroinflammatory responses in diabetic retinopathy.
J Neuroinflammation. 2015 Aug 07; 12:141.JN

Abstract

Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as a vascular dysfunction leading to blindness in working-age adults. It becomes increasingly clear that neural cells in retina play an important role in the pathogenesis of DR. Neural retina located at the back of the eye is part of the brain and a representative of the central nervous system. The neurosensory deficits seen in DR are related to inflammation and occur prior to the clinically identifiable vascular complications. The neural deficits are associated with abnormal reactions of retina glial cells and neurons in response to hyperglycemia. Improper activation of the innate immune system may also be an important contributor to the pathophysiology of DR. Therefore, DR manifests characteristics of both vasculopathy and chronic neuroinflammatory diseases. In this article, we attempt to provide an overview of the current understanding of inflammation in neural retina abnormalities in diabetes. Inhibition of neuroinflammation may represent a novel therapeutic strategy to the prevention of the progression of DR.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S Xianlie Road, Guangzhou, 510060, China. yuying.2009@163.com.Eye Institute, Affiliated Hospital of Nantong University, Nantong, 226001, China. chenhuieye@126.com.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S Xianlie Road, Guangzhou, 510060, China. sushaobo7836@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26245868

Citation

Yu, Ying, et al. "Neuroinflammatory Responses in Diabetic Retinopathy." Journal of Neuroinflammation, vol. 12, 2015, p. 141.
Yu Y, Chen H, Su SB. Neuroinflammatory responses in diabetic retinopathy. J Neuroinflammation. 2015;12:141.
Yu, Y., Chen, H., & Su, S. B. (2015). Neuroinflammatory responses in diabetic retinopathy. Journal of Neuroinflammation, 12, 141. https://doi.org/10.1186/s12974-015-0368-7
Yu Y, Chen H, Su SB. Neuroinflammatory Responses in Diabetic Retinopathy. J Neuroinflammation. 2015 Aug 7;12:141. PubMed PMID: 26245868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroinflammatory responses in diabetic retinopathy. AU - Yu,Ying, AU - Chen,Hui, AU - Su,Shao Bo, Y1 - 2015/08/07/ PY - 2015/04/13/received PY - 2015/07/27/accepted PY - 2015/8/7/entrez PY - 2015/8/8/pubmed PY - 2016/3/24/medline SP - 141 EP - 141 JF - Journal of neuroinflammation JO - J Neuroinflammation VL - 12 N2 - Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as a vascular dysfunction leading to blindness in working-age adults. It becomes increasingly clear that neural cells in retina play an important role in the pathogenesis of DR. Neural retina located at the back of the eye is part of the brain and a representative of the central nervous system. The neurosensory deficits seen in DR are related to inflammation and occur prior to the clinically identifiable vascular complications. The neural deficits are associated with abnormal reactions of retina glial cells and neurons in response to hyperglycemia. Improper activation of the innate immune system may also be an important contributor to the pathophysiology of DR. Therefore, DR manifests characteristics of both vasculopathy and chronic neuroinflammatory diseases. In this article, we attempt to provide an overview of the current understanding of inflammation in neural retina abnormalities in diabetes. Inhibition of neuroinflammation may represent a novel therapeutic strategy to the prevention of the progression of DR. SN - 1742-2094 UR - https://www.unboundmedicine.com/medline/citation/26245868/Neuroinflammatory_responses_in_diabetic_retinopathy_ L2 - https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0368-7 DB - PRIME DP - Unbound Medicine ER -