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Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation.
Nutrients. 2015 Aug 04; 7(8):6390-404.N

Abstract

The role of the long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in lipid metabolism and inflammation has been extensively studied; however, little is known about the relationship between docosapentaenoic acid (DPA, 22:5 n-3) and inflammation and triglycerides (TG). We evaluated whether n-3 DPA content of red blood cells (RBC) was associated with markers of inflammation (interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and C-reactive protein (CRP) and fasting TG prior to n-3 supplementation in two studies (Study 1: n = 115, aged 20-44 years, body mass index (BMI) 20-30 kg/m2, TG = 34-176 mg/dL; Study 2: n = 28, aged 22-65 years, BMI 24-37 kg/m2, TG = 141-339 mg/dL). We also characterized the dose-response effects of n-3 fatty acid supplementation on RBC n-3 DPA after five months of supplementation with fish oil (Study 1: 0, 300, 600, 900, and 1800 mg/day EPA + DHA) and eight weeks of prescription n-3 ethyl esters (Study 2: 0, 850, and 3400 mg/day EPA + DHA). In Study 1, RBC n-3 DPA was inversely correlated with CRP (R2 = 36%, p < 0.001) and with fasting TG (r = -0.30, p = 0.001). The latter finding was replicated in Study 2 (r = -0.33, p = 0.04). In both studies, n-3 supplementation significantly increased RBC n-3 DPA dose-dependently. Relative increases were greater for Study 1, with increases of 29%-61% vs. 14%-26% for Study 2. The associations between RBC n-3 DPA, CRP, and fasting TG may have important implications for the prevention of atherosclerosis and chronic inflammatory diseases and warrant further study.

Authors+Show Affiliations

Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. aus164@psu.edu.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. mike.flock@gmail.com.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. ckr129@psu.edu.OmegaQuant Analytics, LLC, Sioux Falls, SD 57106, USA. Bill@omegaquant.com.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. sgw2@psu.edu. Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA. sgw2@psu.edu.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. pmk3@psu.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26247967

Citation

Skulas-Ray, Ann C., et al. "Red Blood Cell Docosapentaenoic Acid (DPA N-3) Is Inversely Associated With Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following N-3 Fatty Acid Supplementation." Nutrients, vol. 7, no. 8, 2015, pp. 6390-404.
Skulas-Ray AC, Flock MR, Richter CK, et al. Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation. Nutrients. 2015;7(8):6390-404.
Skulas-Ray, A. C., Flock, M. R., Richter, C. K., Harris, W. S., West, S. G., & Kris-Etherton, P. M. (2015). Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation. Nutrients, 7(8), 6390-404. https://doi.org/10.3390/nu7085291
Skulas-Ray AC, et al. Red Blood Cell Docosapentaenoic Acid (DPA N-3) Is Inversely Associated With Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following N-3 Fatty Acid Supplementation. Nutrients. 2015 Aug 4;7(8):6390-404. PubMed PMID: 26247967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation. AU - Skulas-Ray,Ann C, AU - Flock,Michael R, AU - Richter,Chesney K, AU - Harris,William S, AU - West,Sheila G, AU - Kris-Etherton,Penny M, Y1 - 2015/08/04/ PY - 2015/06/01/received PY - 2015/06/01/revised PY - 2015/07/21/accepted PY - 2015/8/7/entrez PY - 2015/8/8/pubmed PY - 2016/5/20/medline KW - DPA KW - fish oil KW - inflammation KW - marine omega-3 fatty acids SP - 6390 EP - 404 JF - Nutrients JO - Nutrients VL - 7 IS - 8 N2 - The role of the long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in lipid metabolism and inflammation has been extensively studied; however, little is known about the relationship between docosapentaenoic acid (DPA, 22:5 n-3) and inflammation and triglycerides (TG). We evaluated whether n-3 DPA content of red blood cells (RBC) was associated with markers of inflammation (interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and C-reactive protein (CRP) and fasting TG prior to n-3 supplementation in two studies (Study 1: n = 115, aged 20-44 years, body mass index (BMI) 20-30 kg/m2, TG = 34-176 mg/dL; Study 2: n = 28, aged 22-65 years, BMI 24-37 kg/m2, TG = 141-339 mg/dL). We also characterized the dose-response effects of n-3 fatty acid supplementation on RBC n-3 DPA after five months of supplementation with fish oil (Study 1: 0, 300, 600, 900, and 1800 mg/day EPA + DHA) and eight weeks of prescription n-3 ethyl esters (Study 2: 0, 850, and 3400 mg/day EPA + DHA). In Study 1, RBC n-3 DPA was inversely correlated with CRP (R2 = 36%, p < 0.001) and with fasting TG (r = -0.30, p = 0.001). The latter finding was replicated in Study 2 (r = -0.33, p = 0.04). In both studies, n-3 supplementation significantly increased RBC n-3 DPA dose-dependently. Relative increases were greater for Study 1, with increases of 29%-61% vs. 14%-26% for Study 2. The associations between RBC n-3 DPA, CRP, and fasting TG may have important implications for the prevention of atherosclerosis and chronic inflammatory diseases and warrant further study. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26247967/Red_Blood_Cell_Docosapentaenoic_Acid__DPA_n_3__is_Inversely_Associated_with_Triglycerides_and_C_reactive_Protein__CRP__in_Healthy_Adults_and_Dose_Dependently_Increases_Following_n_3_Fatty_Acid_Supplementation_ L2 - https://www.mdpi.com/resolver?pii=nu7085291 DB - PRIME DP - Unbound Medicine ER -