SOST polymorphisms and response to alendronate treatment in postmenopausal Chinese women with osteoporosis.Pharmacogenomics. 2015; 16(10):1077-88.P
To investigate the association between SOST gene polymorphisms and response to alendronate treatment.
MATERIALS & METHODS
639 Chinese postmenopausal women with osteoporosis or osteopenia received alendronate treatment. Polymorphisms of SOST were analyzed. Bone mineral density (BMD), serum ALP and β-CTX levels were measured. The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed.
rs1234612 and rs851054 polymorphisms were correlated to baseline lumbar spine BMD (p < 0.05). After 12 months of treatment rs1234612 and rs865429 polymorphisms were correlated to BMD changes at the lumbar spine (p < 0.05) or femoral neck (p < 0.05), respectively.
The polymorphisms of SOST are genetic factors affecting bone health and response to alendronate in Chinese postmenopausal women.