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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.
Science. 2015 Aug 07; 349(6248):1255555.Sci

Abstract

The pathological assembly of Aβ, tau, and α-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular deposits of Aβ and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of α-synuclein make up the Lewy pathology of Parkinson's disease. Most cases of disease are sporadic, but some are inherited in a dominant manner. Mutations frequently occur in the genes encoding Aβ, tau, and α-synuclein. Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific regions of the brain during the process of Alzheimer's and Parkinson's diseases, from where it spreads to other areas.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Goedert M
Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. mg@mrc-lmb.cam.ac.uk.

MeSH

Alzheimer DiseaseAmyloid beta-Protein PrecursorBrainHumansLewy BodiesMutationParkinson DiseasePrion DiseasesPrion ProteinsPrionsalpha-Synucleintau Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26250687

Citation

Goedert, Michel. "NEURODEGENERATION. Alzheimer's and Parkinson's Diseases: the Prion Concept in Relation to Assembled Aβ, Tau, and Α-synuclein." Science (New York, N.Y.), vol. 349, no. 6248, 2015, p. 1255555.
Goedert M. NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science. 2015;349(6248):1255555.
Goedert, M. (2015). NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science (New York, N.Y.), 349(6248), 1255555. https://doi.org/10.1126/science.1255555
Goedert M. NEURODEGENERATION. Alzheimer's and Parkinson's Diseases: the Prion Concept in Relation to Assembled Aβ, Tau, and Α-synuclein. Science. 2015 Aug 7;349(6248):1255555. PubMed PMID: 26250687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. A1 - Goedert,Michel, PY - 2015/8/8/entrez PY - 2015/8/8/pubmed PY - 2015/9/4/medline SP - 1255555 EP - 1255555 JF - Science (New York, N.Y.) JO - Science VL - 349 IS - 6248 N2 - The pathological assembly of Aβ, tau, and α-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular deposits of Aβ and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of α-synuclein make up the Lewy pathology of Parkinson's disease. Most cases of disease are sporadic, but some are inherited in a dominant manner. Mutations frequently occur in the genes encoding Aβ, tau, and α-synuclein. Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific regions of the brain during the process of Alzheimer's and Parkinson's diseases, from where it spreads to other areas. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/26250687/NEURODEGENERATION__Alzheimer's_and_Parkinson's_diseases:_The_prion_concept_in_relation_to_assembled_A��_tau_and_��_synuclein_ DB - PRIME DP - Unbound Medicine ER -