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Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-F(tox) approach.
Environ Sci Pollut Res Int. 2015 Dec; 22(23):19213-23.ES

Abstract

There are only a limited number of studies that have developed appropriate models which incorporate bioavailability to estimate mixture toxicity. Here, we explored the applicability of the extended biotic ligand model (BLM) and the WHAM-F(tox) approach for predicting and interpreting mixture toxicity, with the assumption that interactions between metal ions obey the BLM theory. Seedlings of lettuce Lactuca sativa were exposed to metal mixtures (Cu-Ni, Cu-Cd, and Ni-Cd) contained in hydroponic solutions for 4 days. Inhibition to root elongation was the endpoint used to quantify the toxic response. Assuming that metal ions compete with each other for binding at a single biotic ligand, the extended BLM succeeded in predicting toxicity of three mixtures to lettuce, with more than 82% of toxicity variation explained. There were no significant differences in the values of f(mix50) (i.e., the overall amounts of metal ions bound to the biotic ligand inducing 50% effect) for the three mixture combinations, showing the possibility of extrapolating these values to other binary metal combinations. The WHAM-F(tox) approach showed a similar level of precision in estimating mixture toxicity while requiring fewer parameters than the BLM-f(mix) model. External validation of the WHAM-F(tox) approach using literature data showed its applicability for other species and other mixtures. The WHAM-F(tox) model is suitable for delineating mixture effects where the extended BLM also applies. Therefore, in case of lower data availability, we recommend the lower parameterized WHAM-F(tox) as an effective approach to incorporate bioavailability in quantifying mixture toxicity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Qiu H
Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands. Division Soil and Water Management, KU Leuven, Heverlee, Belgium.
Vijver MG
Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands.
He E
Division Soil and Water Management, KU Leuven, Heverlee, Belgium. e2.he@vu.nl. Department of Ecological Science, VU University, Amsterdam, The Netherlands. e2.he@vu.nl.
Liu Y
Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands.
Wang P
School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Xia B
Department of Hydrology, University of Bayreuth, Bayreuth, Germany.
Smolders E
Division Soil and Water Management, KU Leuven, Heverlee, Belgium.
Versieren L
Division Soil and Water Management, KU Leuven, Heverlee, Belgium.
Peijnenburg WJ
Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands. National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

MeSH

CadmiumComplex MixturesCopperHydroponicsLettuceLigandsModels, ChemicalNickelPlant RootsSeedlingsSolutionsWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26250821

Citation

Qiu, Hao, et al. "Incorporating Bioavailability Into Toxicity Assessment of Cu-Ni, Cu-Cd, and Ni-Cd Mixtures With the Extended Biotic Ligand Model and the WHAM-F(tox) Approach." Environmental Science and Pollution Research International, vol. 22, no. 23, 2015, pp. 19213-23.
Qiu H, Vijver MG, He E, et al. Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-F(tox) approach. Environ Sci Pollut Res Int. 2015;22(23):19213-23.
Qiu, H., Vijver, M. G., He, E., Liu, Y., Wang, P., Xia, B., Smolders, E., Versieren, L., & Peijnenburg, W. J. (2015). Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-F(tox) approach. Environmental Science and Pollution Research International, 22(23), 19213-23. https://doi.org/10.1007/s11356-015-5130-2
Qiu H, et al. Incorporating Bioavailability Into Toxicity Assessment of Cu-Ni, Cu-Cd, and Ni-Cd Mixtures With the Extended Biotic Ligand Model and the WHAM-F(tox) Approach. Environ Sci Pollut Res Int. 2015;22(23):19213-23. PubMed PMID: 26250821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporating bioavailability into toxicity assessment of Cu-Ni, Cu-Cd, and Ni-Cd mixtures with the extended biotic ligand model and the WHAM-F(tox) approach. AU - Qiu,Hao, AU - Vijver,Martina G, AU - He,Erkai, AU - Liu,Yang, AU - Wang,Peng, AU - Xia,Bing, AU - Smolders,Erik, AU - Versieren,Liske, AU - Peijnenburg,Willie J G M, Y1 - 2015/08/08/ PY - 2015/03/20/received PY - 2015/07/27/accepted PY - 2015/8/8/entrez PY - 2015/8/8/pubmed PY - 2016/7/21/medline KW - Bioavailability KW - Biotic ligand model KW - Metals KW - Mixture interactions KW - Toxicity KW - WHAM-F tox SP - 19213 EP - 23 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 22 IS - 23 N2 - There are only a limited number of studies that have developed appropriate models which incorporate bioavailability to estimate mixture toxicity. Here, we explored the applicability of the extended biotic ligand model (BLM) and the WHAM-F(tox) approach for predicting and interpreting mixture toxicity, with the assumption that interactions between metal ions obey the BLM theory. Seedlings of lettuce Lactuca sativa were exposed to metal mixtures (Cu-Ni, Cu-Cd, and Ni-Cd) contained in hydroponic solutions for 4 days. Inhibition to root elongation was the endpoint used to quantify the toxic response. Assuming that metal ions compete with each other for binding at a single biotic ligand, the extended BLM succeeded in predicting toxicity of three mixtures to lettuce, with more than 82% of toxicity variation explained. There were no significant differences in the values of f(mix50) (i.e., the overall amounts of metal ions bound to the biotic ligand inducing 50% effect) for the three mixture combinations, showing the possibility of extrapolating these values to other binary metal combinations. The WHAM-F(tox) approach showed a similar level of precision in estimating mixture toxicity while requiring fewer parameters than the BLM-f(mix) model. External validation of the WHAM-F(tox) approach using literature data showed its applicability for other species and other mixtures. The WHAM-F(tox) model is suitable for delineating mixture effects where the extended BLM also applies. Therefore, in case of lower data availability, we recommend the lower parameterized WHAM-F(tox) as an effective approach to incorporate bioavailability in quantifying mixture toxicity. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/26250821/Incorporating_bioavailability_into_toxicity_assessment_of_Cu_Ni_Cu_Cd_and_Ni_Cd_mixtures_with_the_extended_biotic_ligand_model_and_the_WHAM_F_tox__approach_ DB - PRIME DP - Unbound Medicine ER -