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Assessment of the lung toxicity of copper oxide nanoparticles: current status.
Nanomedicine (Lond). 2015; 10(15):2365-77.N

Abstract

Copper oxide nanoparticles (CuO NPs) are being used in several industrial and commercial products. Inhalation is one of the most significant routes of metal oxide NP exposure. Hence, the toxicity of CuO NPs in lung tissues is of great concern. In vitro studies have indicated that CuO NPs induce cytotoxicity, oxidative stress and genetic toxicity in cultivated human lung cells. Leaching of Cu ions, reactive oxygen species generation and autophagy appear to be the underlying mechanisms of Cu NP toxicity in lung cells. In vivo studies on the lung toxicity of CuO NPs are largely lacking. Some studies have shown that intratracheal instillation of CuO NPs induced oxidative stress, inflammation and neoplastic lesions in rats. This review critically assessed the current findings of the toxicity of CuO NPs in the lung.

Authors+Show Affiliations

King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia.King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia.King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia. Department of Physics & Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26251192

Citation

Ahamed, Maqusood, et al. "Assessment of the Lung Toxicity of Copper Oxide Nanoparticles: Current Status." Nanomedicine (London, England), vol. 10, no. 15, 2015, pp. 2365-77.
Ahamed M, Akhtar MJ, Alhadlaq HA, et al. Assessment of the lung toxicity of copper oxide nanoparticles: current status. Nanomedicine (Lond). 2015;10(15):2365-77.
Ahamed, M., Akhtar, M. J., Alhadlaq, H. A., & Alrokayan, S. A. (2015). Assessment of the lung toxicity of copper oxide nanoparticles: current status. Nanomedicine (London, England), 10(15), 2365-77. https://doi.org/10.2217/nnm.15.72
Ahamed M, et al. Assessment of the Lung Toxicity of Copper Oxide Nanoparticles: Current Status. Nanomedicine (Lond). 2015;10(15):2365-77. PubMed PMID: 26251192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of the lung toxicity of copper oxide nanoparticles: current status. AU - Ahamed,Maqusood, AU - Akhtar,Mohd Javed, AU - Alhadlaq,Hisham A, AU - Alrokayan,Salman A, Y1 - 2015/08/07/ PY - 2015/8/8/entrez PY - 2015/8/8/pubmed PY - 2016/6/9/medline KW - Cu ions KW - ROS KW - apoptosis KW - autophagy KW - copper oxide nanoparticles KW - lung toxicity KW - oxidative stress SP - 2365 EP - 77 JF - Nanomedicine (London, England) JO - Nanomedicine (Lond) VL - 10 IS - 15 N2 - Copper oxide nanoparticles (CuO NPs) are being used in several industrial and commercial products. Inhalation is one of the most significant routes of metal oxide NP exposure. Hence, the toxicity of CuO NPs in lung tissues is of great concern. In vitro studies have indicated that CuO NPs induce cytotoxicity, oxidative stress and genetic toxicity in cultivated human lung cells. Leaching of Cu ions, reactive oxygen species generation and autophagy appear to be the underlying mechanisms of Cu NP toxicity in lung cells. In vivo studies on the lung toxicity of CuO NPs are largely lacking. Some studies have shown that intratracheal instillation of CuO NPs induced oxidative stress, inflammation and neoplastic lesions in rats. This review critically assessed the current findings of the toxicity of CuO NPs in the lung. SN - 1748-6963 UR - https://www.unboundmedicine.com/medline/citation/26251192/Assessment_of_the_lung_toxicity_of_copper_oxide_nanoparticles:_current_status_ L2 - https://www.futuremedicine.com/doi/10.2217/nnm.15.72?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -