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Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis.
Eur J Pharmacol. 1989 Dec 07; 173(2-3):133-41.EJ

Abstract

A brain dialysis technique was used to investigate the effects of cholinergic drugs on acetylcholine (ACh) release and on the extracellular choline levels. Scopolamine (0.5 mg/kg s.c.) markedly increased ACh release in frontal cortex, hippocampus and corpus striatum. Conversely, it significantly decreased choline levels in extracellular spaces of these three regions. Oxotremorine (0.5 mg/kg i.p.) induced no significant ACh release in these three regions, probably due to the presence of highly concentrated physostigmine in the perfusate, while it induced an increase of the choline levels in both frontal cortex and hippocampus but not in corpus striatum. Nicotine (0.5 mg/kg s.c.) significantly increased the ACh release in these three regions with no change in choline levels. Nicotine had a biphasic effect on ACh release in frontal cortex and hippocampus but not in corpus striatum. It should be noted that all such cholinergic drugs, in our time course determinations, yielded certain differences among these brain regions for both the magnitude and the response pattern of ACh and choline levels. The present investigation appears to indicate that the in vivo brain dialysis technique can be useful for probing cholinergic neurotransmission of cholinergic drugs via presynaptic terminals.

Authors+Show Affiliations

Section of Pharmacology, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2625133

Citation

Toide, K, and T Arima. "Effects of Cholinergic Drugs On Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied By Brain Dialysis." European Journal of Pharmacology, vol. 173, no. 2-3, 1989, pp. 133-41.
Toide K, Arima T. Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis. Eur J Pharmacol. 1989;173(2-3):133-41.
Toide, K., & Arima, T. (1989). Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis. European Journal of Pharmacology, 173(2-3), 133-41.
Toide K, Arima T. Effects of Cholinergic Drugs On Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied By Brain Dialysis. Eur J Pharmacol. 1989 Dec 7;173(2-3):133-41. PubMed PMID: 2625133.
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TY - JOUR T1 - Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis. AU - Toide,K, AU - Arima,T, PY - 1989/12/7/pubmed PY - 1989/12/7/medline PY - 1989/12/7/entrez SP - 133 EP - 41 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 173 IS - 2-3 N2 - A brain dialysis technique was used to investigate the effects of cholinergic drugs on acetylcholine (ACh) release and on the extracellular choline levels. Scopolamine (0.5 mg/kg s.c.) markedly increased ACh release in frontal cortex, hippocampus and corpus striatum. Conversely, it significantly decreased choline levels in extracellular spaces of these three regions. Oxotremorine (0.5 mg/kg i.p.) induced no significant ACh release in these three regions, probably due to the presence of highly concentrated physostigmine in the perfusate, while it induced an increase of the choline levels in both frontal cortex and hippocampus but not in corpus striatum. Nicotine (0.5 mg/kg s.c.) significantly increased the ACh release in these three regions with no change in choline levels. Nicotine had a biphasic effect on ACh release in frontal cortex and hippocampus but not in corpus striatum. It should be noted that all such cholinergic drugs, in our time course determinations, yielded certain differences among these brain regions for both the magnitude and the response pattern of ACh and choline levels. The present investigation appears to indicate that the in vivo brain dialysis technique can be useful for probing cholinergic neurotransmission of cholinergic drugs via presynaptic terminals. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/2625133/Effects_of_cholinergic_drugs_on_extracellular_levels_of_acetylcholine_and_choline_in_rat_cortex_hippocampus_and_striatum_studied_by_brain_dialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(89)90510-4 DB - PRIME DP - Unbound Medicine ER -