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A quality improvement project to improve early sepsis care in the emergency department.
BMJ Qual Saf. 2015 Dec; 24(12):787-95.BQ

Abstract

BACKGROUND

Sepsis causes substantial morbidity and mortality in hospitalised patients. Although many studies describe the use of protocols in the management of patients with severe sepsis and septic shock, few have addressed emergency department (ED) screening and management for patients initially presenting with uncomplicated sepsis (ie, patients without organ failure or hypotension).

OBJECTIVE

A quality improvement task force at a large, quaternary care referral hospital sought to develop a protocol focusing on early identification of patients with uncomplicated sepsis, in addition to severe sepsis and septic shock.

INTERVENTION

The three-tiered intervention consisted of (1) a nurse-driven screening tool and management protocol to identify and initiate early treatment of patients with sepsis, (2) a computer-assisted screening algorithm that generated a 'Sepsis Alert' pop-up screen in the electronic medical record for treating clinical healthcare providers and (3) automated suggested sepsis-specific order sets for initial workup and resuscitation, antibiotic selection and goal-directed therapy.

DESIGN

A before and after retrospective cohort study was undertaken to determine the intervention's impact on compliance with recommended sepsis management, including serum lactate measured in the ED, 2 L of intravenous fluid administered within 2 h of triage, antibiotics administered within 3 h of triage and blood cultures drawn before antibiotic administration. Mortality rates for patients in the ED with a sepsis-designated ICD-9 code present on admission were also analysed.

RESULTS

Overall bundle compliance increased by 154%, from 28% at baseline to 71% in the last quarter of the study (p<0.001). Bundle, antibiotic and intravenous fluid compliance all increased significantly after launch of the sepsis initiative (eg, bundle and intravenous fluid compliance increased by 74% and 54%, respectively; p<0.001). Bundle and antibiotic compliance both showed further significant increases after implementation of suggested order sets (31% and 25% increases, respectively; p<0.001). The mortality rate for patients in the ED admitted with sepsis was 13.3% before implementation and fell to 11.1% after (p=0.230); mortality in the last two quarters of the study was 9.3% (p=0.107).

CONCLUSIONS

The new protocol demonstrates that early screening interventions can lead to expedited delivery of care to patients with sepsis in the ED and could serve as a model for other facilities. Mortality was not significantly improved by our intervention, which included patients with uncomplicated sepsis.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Gatewood MO
Division of Emergency Medicine, University of Washington Medical Center, Seattle, Washington, USA.
Wemple M
Division of Pulmonary & Critical Care Medicine, VA Puget Sound Health Care System, Seattle, Washington, USA.
Greco S
Divisions of Critical Care and Cardiology, Patient Care Services, University of Washington Medical Center, Seattle, Washington, USA.
Kritek PA
Division of Pulmonary & Critical Care Medicine, University of Washington Medical Center, Seattle, Washington, USA.
Durvasula R
Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA.

MeSH

AlgorithmsClinical ProtocolsDiagnosis, Computer-AssistedEmergency Service, HospitalGuideline AdherenceHumansMass ScreeningPatient Care BundlesPractice Guidelines as TopicQuality ImprovementResuscitationRetrospective StudiesSepsisShock, Septic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26251506

Clinical Trial Links

Effects of External Inspection on Sepsis Detection and Treatment

Citation

Gatewood, Medley O'Keefe, et al. "A Quality Improvement Project to Improve Early Sepsis Care in the Emergency Department." BMJ Quality & Safety, vol. 24, no. 12, 2015, pp. 787-95.
Gatewood MO, Wemple M, Greco S, et al. A quality improvement project to improve early sepsis care in the emergency department. BMJ Qual Saf. 2015;24(12):787-95.
Gatewood, M. O., Wemple, M., Greco, S., Kritek, P. A., & Durvasula, R. (2015). A quality improvement project to improve early sepsis care in the emergency department. BMJ Quality & Safety, 24(12), 787-95. https://doi.org/10.1136/bmjqs-2014-003552
Gatewood MO, et al. A Quality Improvement Project to Improve Early Sepsis Care in the Emergency Department. BMJ Qual Saf. 2015;24(12):787-95. PubMed PMID: 26251506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A quality improvement project to improve early sepsis care in the emergency department. AU - Gatewood,Medley O'Keefe, AU - Wemple,Matthew, AU - Greco,Sheryl, AU - Kritek,Patricia A, AU - Durvasula,Raghu, Y1 - 2015/08/06/ PY - 2014/09/05/received PY - 2015/07/18/accepted PY - 2015/8/8/entrez PY - 2015/8/8/pubmed PY - 2017/1/31/medline KW - Critical care KW - Emergency department KW - Information technology KW - Performance measures KW - Quality improvement SP - 787 EP - 95 JF - BMJ quality & safety JO - BMJ Qual Saf VL - 24 IS - 12 N2 - BACKGROUND: Sepsis causes substantial morbidity and mortality in hospitalised patients. Although many studies describe the use of protocols in the management of patients with severe sepsis and septic shock, few have addressed emergency department (ED) screening and management for patients initially presenting with uncomplicated sepsis (ie, patients without organ failure or hypotension). OBJECTIVE: A quality improvement task force at a large, quaternary care referral hospital sought to develop a protocol focusing on early identification of patients with uncomplicated sepsis, in addition to severe sepsis and septic shock. INTERVENTION: The three-tiered intervention consisted of (1) a nurse-driven screening tool and management protocol to identify and initiate early treatment of patients with sepsis, (2) a computer-assisted screening algorithm that generated a 'Sepsis Alert' pop-up screen in the electronic medical record for treating clinical healthcare providers and (3) automated suggested sepsis-specific order sets for initial workup and resuscitation, antibiotic selection and goal-directed therapy. DESIGN: A before and after retrospective cohort study was undertaken to determine the intervention's impact on compliance with recommended sepsis management, including serum lactate measured in the ED, 2 L of intravenous fluid administered within 2 h of triage, antibiotics administered within 3 h of triage and blood cultures drawn before antibiotic administration. Mortality rates for patients in the ED with a sepsis-designated ICD-9 code present on admission were also analysed. RESULTS: Overall bundle compliance increased by 154%, from 28% at baseline to 71% in the last quarter of the study (p<0.001). Bundle, antibiotic and intravenous fluid compliance all increased significantly after launch of the sepsis initiative (eg, bundle and intravenous fluid compliance increased by 74% and 54%, respectively; p<0.001). Bundle and antibiotic compliance both showed further significant increases after implementation of suggested order sets (31% and 25% increases, respectively; p<0.001). The mortality rate for patients in the ED admitted with sepsis was 13.3% before implementation and fell to 11.1% after (p=0.230); mortality in the last two quarters of the study was 9.3% (p=0.107). CONCLUSIONS: The new protocol demonstrates that early screening interventions can lead to expedited delivery of care to patients with sepsis in the ED and could serve as a model for other facilities. Mortality was not significantly improved by our intervention, which included patients with uncomplicated sepsis. SN - 2044-5423 UR - https://www.unboundmedicine.com/medline/citation/26251506/A_quality_improvement_project_to_improve_early_sepsis_care_in_the_emergency_department_ DB - PRIME DP - Unbound Medicine ER -