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Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review.
Onco Targets Ther 2015; 8:1909-14OT

Abstract

Glomus tumor is an exceedingly rare neoplasm that is derived from cells of the neuromyoarterial glomus or glomus body. It rarely occurs in the visceral organs where glomus body may be sparse or even absent, such as the stomach, intestines, mediastinum, and respiratory tract. It is unusual for a glomus tumor to demonstrate atypical or malignant histopathological characteristics. It is also rare for such a tumor to express clinically aggressive behavior. However, when metastasis does occur, this disease is often fatal. We herein report an interesting case of a middle-age woman admitted due to progressive cough and hemoptysis. A polypoid mass was found to occlude the left lingular lobar bronchus. Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin. Two months later, the patient developed abdominal distension and gastrointestinal bleeding. Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland. We further entail a review of the literature on the clinicopathologic features and diagnosis of this uncommon tumor.

Authors+Show Affiliations

Department of Pulmonary Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.Department of Pulmonary Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.Department of Internal Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.Department of Pulmonary Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

26251614

Citation

Dong, Liang-Liang, et al. "Malignant Glomus Tumor of the Lung With Multiorgan Metastases: Case Report and Literature Review." OncoTargets and Therapy, vol. 8, 2015, pp. 1909-14.
Dong LL, Chen EG, Sheikh IS, et al. Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review. Onco Targets Ther. 2015;8:1909-14.
Dong, L. L., Chen, E. G., Sheikh, I. S., Jiang, Z. N., Huang, A. H., & Ying, K. J. (2015). Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review. OncoTargets and Therapy, 8, pp. 1909-14. doi:10.2147/OTT.S89396.
Dong LL, et al. Malignant Glomus Tumor of the Lung With Multiorgan Metastases: Case Report and Literature Review. Onco Targets Ther. 2015;8:1909-14. PubMed PMID: 26251614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review. AU - Dong,Liang-Liang, AU - Chen,En-Guo, AU - Sheikh,Irfan S, AU - Jiang,Zhi-Nong, AU - Huang,Ai-Hua, AU - Ying,Ke-Jing, Y1 - 2015/07/28/ PY - 2015/8/8/entrez PY - 2015/8/8/pubmed PY - 2015/8/8/medline KW - diagnosis KW - immunohistochemistry KW - lung KW - malignant glomus tumor KW - metastasis SP - 1909 EP - 14 JF - OncoTargets and therapy JO - Onco Targets Ther VL - 8 N2 - Glomus tumor is an exceedingly rare neoplasm that is derived from cells of the neuromyoarterial glomus or glomus body. It rarely occurs in the visceral organs where glomus body may be sparse or even absent, such as the stomach, intestines, mediastinum, and respiratory tract. It is unusual for a glomus tumor to demonstrate atypical or malignant histopathological characteristics. It is also rare for such a tumor to express clinically aggressive behavior. However, when metastasis does occur, this disease is often fatal. We herein report an interesting case of a middle-age woman admitted due to progressive cough and hemoptysis. A polypoid mass was found to occlude the left lingular lobar bronchus. Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin. Two months later, the patient developed abdominal distension and gastrointestinal bleeding. Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland. We further entail a review of the literature on the clinicopathologic features and diagnosis of this uncommon tumor. SN - 1178-6930 UR - https://www.unboundmedicine.com/medline/citation/26251614/Malignant_glomus_tumor_of_the_lung_with_multiorgan_metastases:_case_report_and_literature_review_ L2 - https://dx.doi.org/10.2147/OTT.S89396 DB - PRIME DP - Unbound Medicine ER -