Tags

Type your tag names separated by a space and hit enter

Identification and characterization of three new flavonoids from Rhododendron dauricum.
Chin J Nat Med. 2015 Aug; 13(8):628-33.CJ

Abstract

The present study was designed to determine the major chemical constituents of the leaves of Rhododendron dauricum L. Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated by physicochemical properties and spectral data. The present study identified two new C-methyl flavanones, 5, 7, 3', 5'-tetrahydroxy-6, 8-di-C-methyl flavanone (1) and 5, 4'-dihydroxy-8-C-methylflavanone-7-O-β-D-glucopyranoside (2), and one new flavonoid glycoside, quercetin-3-O-β-D-(6"-O-cinnamoyl)-galactoside (3), along with seven known compounds, including syzalterin (4), poriolin (5), farrerol-7-O-β-D-glucopyranoside (6), myrciacetin (7), quercetin-3-O-β-D-(6-p-hydroxy-benzoyl)-galactoside (8), quercetin-3-O-β-D-(6-p-coumaroyl)-galactoside (9), and 5, 7, 3', 5'-tetrahydroxyl flavanone (10). Compounds 1-3 were determined to be new flavonoids; compounds 4-6 were isolated from this species for the first time; and compounds 7-10 were reported for the first time from this genus.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Lou XW
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Lin QH
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Zhang GY
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Liu WY
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China.
Feng F
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: fengfeng@cpu.edu.cn.
Qu W
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: popoqzh@126.com.

MeSH

FlavanonesFlavonoidsGalactosidesGlucosidesMolecular StructurePlant ExtractsPlant LeavesQuercetinRhododendron

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26253496

Citation

Lou, Xin-Wei, et al. "Identification and Characterization of Three New Flavonoids From Rhododendron Dauricum." Chinese Journal of Natural Medicines, vol. 13, no. 8, 2015, pp. 628-33.
Lou XW, Lin QH, Zhang GY, et al. Identification and characterization of three new flavonoids from Rhododendron dauricum. Chin J Nat Med. 2015;13(8):628-33.
Lou, X. W., Lin, Q. H., Zhang, G. Y., Liu, W. Y., Feng, F., & Qu, W. (2015). Identification and characterization of three new flavonoids from Rhododendron dauricum. Chinese Journal of Natural Medicines, 13(8), 628-33. https://doi.org/10.1016/S1875-5364(15)30059-5
Lou XW, et al. Identification and Characterization of Three New Flavonoids From Rhododendron Dauricum. Chin J Nat Med. 2015;13(8):628-33. PubMed PMID: 26253496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and characterization of three new flavonoids from Rhododendron dauricum. AU - Lou,Xin-Wei, AU - Lin,Qing-Hua, AU - Zhang,Guan-Yu, AU - Liu,Wen-Yuan, AU - Feng,Feng, AU - Qu,Wei, PY - 2014/10/28/received PY - 2015/8/9/entrez PY - 2015/8/9/pubmed PY - 2016/5/25/medline KW - Flavonoids KW - Rhododendron dauricum L. KW - Spectroscopic identification SP - 628 EP - 33 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 13 IS - 8 N2 - The present study was designed to determine the major chemical constituents of the leaves of Rhododendron dauricum L. Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated by physicochemical properties and spectral data. The present study identified two new C-methyl flavanones, 5, 7, 3', 5'-tetrahydroxy-6, 8-di-C-methyl flavanone (1) and 5, 4'-dihydroxy-8-C-methylflavanone-7-O-β-D-glucopyranoside (2), and one new flavonoid glycoside, quercetin-3-O-β-D-(6"-O-cinnamoyl)-galactoside (3), along with seven known compounds, including syzalterin (4), poriolin (5), farrerol-7-O-β-D-glucopyranoside (6), myrciacetin (7), quercetin-3-O-β-D-(6-p-hydroxy-benzoyl)-galactoside (8), quercetin-3-O-β-D-(6-p-coumaroyl)-galactoside (9), and 5, 7, 3', 5'-tetrahydroxyl flavanone (10). Compounds 1-3 were determined to be new flavonoids; compounds 4-6 were isolated from this species for the first time; and compounds 7-10 were reported for the first time from this genus. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/26253496/Identification_and_characterization_of_three_new_flavonoids_from_Rhododendron_dauricum_ DB - PRIME DP - Unbound Medicine ER -