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Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities.
Carbohydr Polym. 2015 Oct 20; 131:315-21.CP

Abstract

Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ray S
Natural Products Laboratory, Department of Chemistry, The University of Burdwan, West Bengal 713 104, India. Electronic address: ray_sayani1988@yahoo.co.uk.
Pujol CA
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales UBA, Ciudad Universitaria, Pabellón 2 Piso 4, 1428 Buenos Aires, Argentina.
Damonte EB
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales UBA, Ciudad Universitaria, Pabellón 2 Piso 4, 1428 Buenos Aires, Argentina.
Ray B
Natural Products Laboratory, Department of Chemistry, The University of Burdwan, West Bengal 713 104, India.

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsGlycosidesHerpesvirus 1, HumanMolecular WeightOligosaccharidesRhodophytaSpectroscopy, Fourier Transform InfraredSulfatesVero Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26256190

Citation

Ray, Sayani, et al. "Additionally Sulfated Xylomannan Sulfates From Scinaia Hatei and Their Antiviral Activities." Carbohydrate Polymers, vol. 131, 2015, pp. 315-21.
Ray S, Pujol CA, Damonte EB, et al. Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities. Carbohydr Polym. 2015;131:315-21.
Ray, S., Pujol, C. A., Damonte, E. B., & Ray, B. (2015). Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities. Carbohydrate Polymers, 131, 315-21. https://doi.org/10.1016/j.carbpol.2015.06.019
Ray S, et al. Additionally Sulfated Xylomannan Sulfates From Scinaia Hatei and Their Antiviral Activities. Carbohydr Polym. 2015 Oct 20;131:315-21. PubMed PMID: 26256190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities. AU - Ray,Sayani, AU - Pujol,Carlos A, AU - Damonte,Elsa B, AU - Ray,Bimalendu, Y1 - 2015/06/14/ PY - 2015/03/28/received PY - 2015/06/01/revised PY - 2015/06/06/accepted PY - 2015/8/11/entrez PY - 2015/8/11/pubmed PY - 2016/6/9/medline KW - Antiviral drug candidate KW - Cytotoxicity KW - Polysaccharide engineering KW - Scinaia hatei SP - 315 EP - 21 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 131 N2 - Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/26256190/Additionally_sulfated_xylomannan_sulfates_from_Scinaia_hatei_and_their_antiviral_activities_ DB - PRIME DP - Unbound Medicine ER -