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Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.
Early Interv Psychiatry. 2017 02; 11(1):77-82.EI

Abstract

AIM

To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort.

METHODS

Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed.

RESULTS

Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5).

CONCLUSIONS

DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.

Authors+Show Affiliations

Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile. Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile. Department of Psychiatry, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.Departamento de Salud Publica, Pontificia Universidad Católica de Chile, Santiago, Chile.Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile. Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26256570

Citation

González-Valderrama, Alfonso, et al. "Duration of Untreated Psychosis and Acute Remission of Negative Symptoms in a South American First-episode Psychosis Cohort." Early Intervention in Psychiatry, vol. 11, no. 1, 2017, pp. 77-82.
González-Valderrama A, Castañeda CP, Mena C, et al. Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort. Early Interv Psychiatry. 2017;11(1):77-82.
González-Valderrama, A., Castañeda, C. P., Mena, C., Undurraga, J., Mondaca, P., Yañez, M., Bedregal, P., & Nachar, R. (2017). Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort. Early Intervention in Psychiatry, 11(1), 77-82. https://doi.org/10.1111/eip.12266
González-Valderrama A, et al. Duration of Untreated Psychosis and Acute Remission of Negative Symptoms in a South American First-episode Psychosis Cohort. Early Interv Psychiatry. 2017;11(1):77-82. PubMed PMID: 26256570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort. AU - González-Valderrama,Alfonso, AU - Castañeda,Carmen Paz, AU - Mena,Cristián, AU - Undurraga,Juan, AU - Mondaca,Pilar, AU - Yañez,Matías, AU - Bedregal,Paula, AU - Nachar,Ruben, Y1 - 2015/08/09/ PY - 2015/02/25/received PY - 2015/07/12/accepted PY - 2015/8/11/pubmed PY - 2017/11/14/medline PY - 2015/8/11/entrez KW - duration of untreated psychosis KW - early intervention KW - negative symptom KW - psychosis KW - schizophrenia SP - 77 EP - 82 JF - Early intervention in psychiatry JO - Early Interv Psychiatry VL - 11 IS - 1 N2 - AIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS: DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms. SN - 1751-7893 UR - https://www.unboundmedicine.com/medline/citation/26256570/Duration_of_untreated_psychosis_and_acute_remission_of_negative_symptoms_in_a_South_American_first_episode_psychosis_cohort_ L2 - https://doi.org/10.1111/eip.12266 DB - PRIME DP - Unbound Medicine ER -