Tags

Type your tag names separated by a space and hit enter

Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships.
Drug Test Anal. 2016 Jul; 8(7):690-701.DT

Abstract

Vaporized cannabis and concurrent cannabis and alcohol intake are commonplace. We evaluated the subjective effects of cannabis, with and without alcohol, relative to blood and oral fluid (OF, advantageous for cannabis exposure screening) cannabinoid concentrations and OF/blood and OF/plasma vaporized-cannabinoid relationships. Healthy adult occasional-to-moderate cannabis smokers received a vaporized placebo or active cannabis (2.9% and 6.7% Δ(9) -tetrahydrocannabinol, THC) with or without oral low-dose alcohol (~0.065g/210L peak breath alcohol concentration [BrAC]) in a within-subjects design. Blood and OF were collected up to 8.3 h post-dose and subjective effects measured at matched time points with visual-analogue scales and 5-point Likert scales. Linear mixed models evaluated subjective effects by THC concentration, BrAC, and interactions. Effects by time point were evaluated by dose-wise analysis of variance (ANOVA). OF versus blood or plasma cannabinoid ratios and correlations were evaluated in paired-positive specimens. Nineteen participants (13 men) completed the study. Blood THC concentration or BrAC significantly associated with subjective effects including 'high', while OF contamination prevented significant OF concentration associations <1.4 h post-dose. Subjective effects persisted through 3.3-4.3 h, with alcohol potentiating the duration of the cannabis effects. Effect-versus-THC concentration and effect-versus-alcohol concentration hystereses were counterclockwise and clockwise, respectively. OF/blood and OF/plasma THC significantly correlated (all Spearman r≥0.71), but variability was high. Vaporized cannabis subjective effects were similar to those previously reported after smoking, with duration extended by concurrent alcohol. Cannabis intake was identified by OF testing, but OF concentration variability limited interpretation. Blood THC concentrations were more consistent across subjects and more accurate at predicting cannabis' subjective effects. Copyright © 2015 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA. Program in Toxicology, University of Maryland, Baltimore, USA.National Advanced Driving Simulator, University of Iowa, Iowa City, IA, USA.College of Pharmacy, University of Iowa, Iowa City, IA, USA.College of Pharmacy, University of Iowa, Iowa City, IA, USA.Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.Carver College of Medicine, University of Iowa, Iowa City, IA, USA.Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26257143

Citation

Hartman, Rebecca L., et al. "Controlled Vaporized Cannabis, With and Without Alcohol: Subjective Effects and Oral Fluid-blood Cannabinoid Relationships." Drug Testing and Analysis, vol. 8, no. 7, 2016, pp. 690-701.
Hartman RL, Brown TL, Milavetz G, et al. Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships. Drug Test Anal. 2016;8(7):690-701.
Hartman, R. L., Brown, T. L., Milavetz, G., Spurgin, A., Gorelick, D. A., Gaffney, G., & Huestis, M. A. (2016). Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships. Drug Testing and Analysis, 8(7), 690-701. https://doi.org/10.1002/dta.1839
Hartman RL, et al. Controlled Vaporized Cannabis, With and Without Alcohol: Subjective Effects and Oral Fluid-blood Cannabinoid Relationships. Drug Test Anal. 2016;8(7):690-701. PubMed PMID: 26257143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships. AU - Hartman,Rebecca L, AU - Brown,Timothy L, AU - Milavetz,Gary, AU - Spurgin,Andrew, AU - Gorelick,David A, AU - Gaffney,Gary, AU - Huestis,Marilyn A, Y1 - 2015/08/10/ PY - 2015/05/11/received PY - 2015/06/11/revised PY - 2015/06/11/accepted PY - 2015/8/11/entrez PY - 2015/8/11/pubmed PY - 2017/3/16/medline KW - alcohol KW - blood KW - cannabis KW - oral fluid KW - subjective SP - 690 EP - 701 JF - Drug testing and analysis JO - Drug Test Anal VL - 8 IS - 7 N2 - Vaporized cannabis and concurrent cannabis and alcohol intake are commonplace. We evaluated the subjective effects of cannabis, with and without alcohol, relative to blood and oral fluid (OF, advantageous for cannabis exposure screening) cannabinoid concentrations and OF/blood and OF/plasma vaporized-cannabinoid relationships. Healthy adult occasional-to-moderate cannabis smokers received a vaporized placebo or active cannabis (2.9% and 6.7% Δ(9) -tetrahydrocannabinol, THC) with or without oral low-dose alcohol (~0.065g/210L peak breath alcohol concentration [BrAC]) in a within-subjects design. Blood and OF were collected up to 8.3 h post-dose and subjective effects measured at matched time points with visual-analogue scales and 5-point Likert scales. Linear mixed models evaluated subjective effects by THC concentration, BrAC, and interactions. Effects by time point were evaluated by dose-wise analysis of variance (ANOVA). OF versus blood or plasma cannabinoid ratios and correlations were evaluated in paired-positive specimens. Nineteen participants (13 men) completed the study. Blood THC concentration or BrAC significantly associated with subjective effects including 'high', while OF contamination prevented significant OF concentration associations <1.4 h post-dose. Subjective effects persisted through 3.3-4.3 h, with alcohol potentiating the duration of the cannabis effects. Effect-versus-THC concentration and effect-versus-alcohol concentration hystereses were counterclockwise and clockwise, respectively. OF/blood and OF/plasma THC significantly correlated (all Spearman r≥0.71), but variability was high. Vaporized cannabis subjective effects were similar to those previously reported after smoking, with duration extended by concurrent alcohol. Cannabis intake was identified by OF testing, but OF concentration variability limited interpretation. Blood THC concentrations were more consistent across subjects and more accurate at predicting cannabis' subjective effects. Copyright © 2015 John Wiley & Sons, Ltd. SN - 1942-7611 UR - https://www.unboundmedicine.com/medline/citation/26257143/Controlled_vaporized_cannabis_with_and_without_alcohol:_subjective_effects_and_oral_fluid_blood_cannabinoid_relationships_ L2 - https://doi.org/10.1002/dta.1839 DB - PRIME DP - Unbound Medicine ER -