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Genital lesions in experimental chronic Trypanosoma brucei infection in rams.
Res Vet Sci 1979; 26(2):145-51RV

Abstract

Rams inoculated intravenously with Trypanosoma brucei developed scrotal oedema and a nonsuppurative granulomatous periorchitis resulting in testicular degeneration, atrophy, calcification and sclerosis. The tunica vaginalis was the seat of an intense granulomatous inflammation and focal necrosis, which extended to the epididymis and spermatic cord. Lesions in the seminal vesicles were suggestive of diminished testosterone production even though Leydig cells were discernible in the sclerotic testicular intertubular tissue. In areas where there was inflammation or focal necrosis, there was also extravascular localisation of trypanosomes. It is suggested that genital lesions in human sleeping sickness may have a similar pathogenetic mechanism involving tissue localisation of the trypanosomes and associated inflammatory and degenerative changes.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

262595

Citation

Ikede, B O.. "Genital Lesions in Experimental Chronic Trypanosoma Brucei Infection in Rams." Research in Veterinary Science, vol. 26, no. 2, 1979, pp. 145-51.
Ikede BO. Genital lesions in experimental chronic Trypanosoma brucei infection in rams. Res Vet Sci. 1979;26(2):145-51.
Ikede, B. O. (1979). Genital lesions in experimental chronic Trypanosoma brucei infection in rams. Research in Veterinary Science, 26(2), pp. 145-51.
Ikede BO. Genital Lesions in Experimental Chronic Trypanosoma Brucei Infection in Rams. Res Vet Sci. 1979;26(2):145-51. PubMed PMID: 262595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genital lesions in experimental chronic Trypanosoma brucei infection in rams. A1 - Ikede,B O, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 145 EP - 51 JF - Research in veterinary science JO - Res. Vet. Sci. VL - 26 IS - 2 N2 - Rams inoculated intravenously with Trypanosoma brucei developed scrotal oedema and a nonsuppurative granulomatous periorchitis resulting in testicular degeneration, atrophy, calcification and sclerosis. The tunica vaginalis was the seat of an intense granulomatous inflammation and focal necrosis, which extended to the epididymis and spermatic cord. Lesions in the seminal vesicles were suggestive of diminished testosterone production even though Leydig cells were discernible in the sclerotic testicular intertubular tissue. In areas where there was inflammation or focal necrosis, there was also extravascular localisation of trypanosomes. It is suggested that genital lesions in human sleeping sickness may have a similar pathogenetic mechanism involving tissue localisation of the trypanosomes and associated inflammatory and degenerative changes. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/262595/Genital_lesions_in_experimental_chronic_Trypanosoma_brucei_infection_in_rams_ DB - PRIME DP - Unbound Medicine ER -