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Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis?
Int J Cardiovasc Imaging. 2015 Dec; 31 Suppl 2:169-76.IJ

Abstract

The relationship of coronary artery disease (CAD) in ex-smokers has not been elucidated, although smoking is considered to be one of the major risk factors of CAD. We investigate subclinical coronary atherosclerosis (SCA) in asymptomatic subjects with coronary computed tomography angiography (CCTA), according to smoking status, and determine whether ex-smokers share a low probability of developing CAD with never-smokers. We retrospectively enrolled 6930 self-referred asymptomatic adults who underwent both coronary artery calcium score (CACS) and CCTA. The prevalence and characteristics of SCA were assessed according to smoking status (never-, ex- and current smokers). After adjusting for variable risk factors, we used multivariate logistic regression for adjusted odds ratios (AOR) of high CACS (>100), SCA (any plaque), significant stenosis (>50 % in luminal stenosis) and each plaque type (non-calcified, mixed and calcified plaque) among the three groups. The prevalence of SCA was highest in the ex-smokers (35.4 %) and the prevalence of significant stenosis in ex-smokers (6.9 %) was as high as in current smokers (6.4 %). However, after adjusting for variable risk factors, SCA was significantly correlated with both ex-smokers (AOR; 1.21) and current smokers (AOR; 1.25), whereas significant stenosis was correlated only with current smokers (AOR; 1.91). The association between SCA and ex-smokers is as strong as with current smokers, although significant stenosis is only correlated with current smokers; thus, not only quitting smoking but also never initiating smoking would be helpful to reduce the progression of the SCA.

Authors+Show Affiliations

Department of Radiology, Seoul Medical Center, Seoul, Korea.Division of Cardiovascular Imaging, Department of Radiology, Seoul National University Bundang Hospital, Gyeonggido, Seoul, 436-707, Korea. drejchun@hanmail.net.Division of Cardiovascular Imaging, Department of Radiology, Seoul National University Bundang Hospital, Gyeonggido, Seoul, 436-707, Korea.Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seoul, Korea.Division of Cardiovascular Imaging, Department of Radiology, Seoul National University Bundang Hospital, Gyeonggido, Seoul, 436-707, Korea.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26259628

Citation

Yi, Minkyung, et al. "Coronary CT Angiography Findings Based On Smoking Status: Do Ex-smokers and Never-smokers Share a Low Probability of Developing Coronary Atherosclerosis?" The International Journal of Cardiovascular Imaging, vol. 31 Suppl 2, 2015, pp. 169-76.
Yi M, Chun EJ, Lee MS, et al. Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis? Int J Cardiovasc Imaging. 2015;31 Suppl 2:169-76.
Yi, M., Chun, E. J., Lee, M. S., Lee, J., & Choi, S. I. (2015). Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis? The International Journal of Cardiovascular Imaging, 31 Suppl 2, 169-76. https://doi.org/10.1007/s10554-015-0738-3
Yi M, et al. Coronary CT Angiography Findings Based On Smoking Status: Do Ex-smokers and Never-smokers Share a Low Probability of Developing Coronary Atherosclerosis. Int J Cardiovasc Imaging. 2015;31 Suppl 2:169-76. PubMed PMID: 26259628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronary CT angiography findings based on smoking status: Do ex-smokers and never-smokers share a low probability of developing coronary atherosclerosis? AU - Yi,Minkyung, AU - Chun,Eun Ju, AU - Lee,Min Su, AU - Lee,Jaebong, AU - Choi,Sang Il, Y1 - 2015/08/11/ PY - 2015/07/16/received PY - 2015/08/07/accepted PY - 2015/8/12/entrez PY - 2015/8/12/pubmed PY - 2016/9/14/medline KW - Coronary artery disease KW - Ex-smoker KW - Multi-detector CT KW - Smoking SP - 169 EP - 76 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 31 Suppl 2 N2 - The relationship of coronary artery disease (CAD) in ex-smokers has not been elucidated, although smoking is considered to be one of the major risk factors of CAD. We investigate subclinical coronary atherosclerosis (SCA) in asymptomatic subjects with coronary computed tomography angiography (CCTA), according to smoking status, and determine whether ex-smokers share a low probability of developing CAD with never-smokers. We retrospectively enrolled 6930 self-referred asymptomatic adults who underwent both coronary artery calcium score (CACS) and CCTA. The prevalence and characteristics of SCA were assessed according to smoking status (never-, ex- and current smokers). After adjusting for variable risk factors, we used multivariate logistic regression for adjusted odds ratios (AOR) of high CACS (>100), SCA (any plaque), significant stenosis (>50 % in luminal stenosis) and each plaque type (non-calcified, mixed and calcified plaque) among the three groups. The prevalence of SCA was highest in the ex-smokers (35.4 %) and the prevalence of significant stenosis in ex-smokers (6.9 %) was as high as in current smokers (6.4 %). However, after adjusting for variable risk factors, SCA was significantly correlated with both ex-smokers (AOR; 1.21) and current smokers (AOR; 1.25), whereas significant stenosis was correlated only with current smokers (AOR; 1.91). The association between SCA and ex-smokers is as strong as with current smokers, although significant stenosis is only correlated with current smokers; thus, not only quitting smoking but also never initiating smoking would be helpful to reduce the progression of the SCA. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/26259628/Coronary_CT_angiography_findings_based_on_smoking_status:_Do_ex_smokers_and_never_smokers_share_a_low_probability_of_developing_coronary_atherosclerosis L2 - https://doi.org/10.1007/s10554-015-0738-3 DB - PRIME DP - Unbound Medicine ER -