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rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom.
Allergy 2015; 70(12):1665-8A

Abstract

Recombinant allergens improve the diagnostic precision in Hymenoptera venom allergy (HVA), in particular in patients with double sensitization to both honey bee (HBV) and yellow jacket venom (YJV). While currently available vespid allergens allow the detection of >95% of YJV-allergic patients, the sensitization frequency to the only available HBV marker allergen rApi m 1 in HBV-allergic patients is lower. Here, we demonstrate that sIgE to additional HBV marker allergens rApi m 3 and rApi m 10 allows the detection of genuine HBV sensitization in 46-65% of Api m 1 negative sera. This is of particular relevance in patients with double sensitization to HBV and YJV that did not identify the culprit insect. Addition of sIgE to rApi m 3 and rApi m 10 provides evidence of HBV sensitization in a large proportion of rApi m 1-negative patients and thus provides a diagnostic marker and rationale for VIT treatment with HBV, which otherwise would have been missing.

Authors+Show Affiliations

Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg.Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg.Immunological Engineering, Department of Engineering, Aarhus University, Aarhus, Denmark.Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg.Thermo Fisher Scientific, Uppsala, Sweden.Immunological Engineering, Department of Engineering, Aarhus University, Aarhus, Denmark.Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26259841

Citation

Frick, M, et al. "RApi M 3 and rApi M 10 Improve Detection of Honey Bee Sensitization in Hymenoptera Venom-allergic Patients With Double Sensitization to Honey Bee and Yellow Jacket Venom." Allergy, vol. 70, no. 12, 2015, pp. 1665-8.
Frick M, Müller S, Bantleon F, et al. RApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom. Allergy. 2015;70(12):1665-8.
Frick, M., Müller, S., Bantleon, F., Huss-Marp, J., Lidholm, J., Spillner, E., & Jakob, T. (2015). RApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom. Allergy, 70(12), pp. 1665-8. doi:10.1111/all.12725.
Frick M, et al. RApi M 3 and rApi M 10 Improve Detection of Honey Bee Sensitization in Hymenoptera Venom-allergic Patients With Double Sensitization to Honey Bee and Yellow Jacket Venom. Allergy. 2015;70(12):1665-8. PubMed PMID: 26259841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom. AU - Frick,M, AU - Müller,S, AU - Bantleon,F, AU - Huss-Marp,J, AU - Lidholm,J, AU - Spillner,E, AU - Jakob,T, Y1 - 2015/09/08/ PY - 2015/08/05/accepted PY - 2015/8/12/entrez PY - 2015/8/12/pubmed PY - 2016/11/10/medline KW - Api m 1 KW - Api m 10 KW - Api m 3 KW - hymenoptera venom allergy KW - recombinant allergens SP - 1665 EP - 8 JF - Allergy JO - Allergy VL - 70 IS - 12 N2 - Recombinant allergens improve the diagnostic precision in Hymenoptera venom allergy (HVA), in particular in patients with double sensitization to both honey bee (HBV) and yellow jacket venom (YJV). While currently available vespid allergens allow the detection of >95% of YJV-allergic patients, the sensitization frequency to the only available HBV marker allergen rApi m 1 in HBV-allergic patients is lower. Here, we demonstrate that sIgE to additional HBV marker allergens rApi m 3 and rApi m 10 allows the detection of genuine HBV sensitization in 46-65% of Api m 1 negative sera. This is of particular relevance in patients with double sensitization to HBV and YJV that did not identify the culprit insect. Addition of sIgE to rApi m 3 and rApi m 10 provides evidence of HBV sensitization in a large proportion of rApi m 1-negative patients and thus provides a diagnostic marker and rationale for VIT treatment with HBV, which otherwise would have been missing. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26259841/rApi_m_3_and_rApi_m_10_improve_detection_of_honey_bee_sensitization_in_Hymenoptera_venom_allergic_patients_with_double_sensitization_to_honey_bee_and_yellow_jacket_venom_ L2 - https://doi.org/10.1111/all.12725 DB - PRIME DP - Unbound Medicine ER -