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A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses.
BMJ Open. 2015 Aug 10; 5(8):e008222.BO

Abstract

OBJECTIVES

To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states.

DESIGN

A systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the Mediterranean diet with a control diet on the treatment of type 2 diabetes and prediabetic states was conducted. Electronic searches were carried out up to January 2015. Trials were included for meta-analyses if they had a control group treated with another diet, if they were of sufficient duration (at least 6 months), and if they had at least 30 participants in each arm. A random-effect model was used to pool data.

PARTICIPANTS

Adults with or at risk for type 2 diabetes.

INTERVENTIONS

Dietary patterns that described themselves as using a 'Mediterranean' dietary pattern.

OUTCOME MEASURES

The outcomes were glycaemic control, cardiovascular risk factors and remission from the metabolic syndrome.

RESULTS

From 2824 studies, 8 meta-analyses and 5 RCTs were eligible. A 'de novo' meta-analysis of 3 long-term (>6 months) RCTs of the Mediterranean diet and glycaemic control of diabetes favoured the Mediterranean diet as compared with lower fat diets. Another 'de novo' meta-analysis of two long-term RCTs showed a 49% increased probability of remission from the metabolic syndrome. 5 meta-analyses showed a favourable effect of the Mediterranean diet, as compared with other diets, on body weight, total cholesterol and high-density lipoprotein cholesterol. 2 meta-analyses demonstrated that higher adherence to the Mediterranean diet reduced the risk of future diabetes by 19-23%.

CONCLUSIONS

The Mediterranean diet was associated with better glycaemic control and cardiovascular risk factors than control diets, including a lower fat diet, suggesting that it is suitable for the overall management of type 2 diabetes.

Authors+Show Affiliations

Diabetes Unit, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.Division of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.Division of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.Medical Statistics Unit, Second University of Naples, Naples, Italy.Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.Division of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26260349

Citation

Esposito, Katherine, et al. "A Journey Into a Mediterranean Diet and Type 2 Diabetes: a Systematic Review With Meta-analyses." BMJ Open, vol. 5, no. 8, 2015, pp. e008222.
Esposito K, Maiorino MI, Bellastella G, et al. A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open. 2015;5(8):e008222.
Esposito, K., Maiorino, M. I., Bellastella, G., Chiodini, P., Panagiotakos, D., & Giugliano, D. (2015). A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open, 5(8), e008222. https://doi.org/10.1136/bmjopen-2015-008222
Esposito K, et al. A Journey Into a Mediterranean Diet and Type 2 Diabetes: a Systematic Review With Meta-analyses. BMJ Open. 2015 Aug 10;5(8):e008222. PubMed PMID: 26260349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. AU - Esposito,Katherine, AU - Maiorino,Maria Ida, AU - Bellastella,Giuseppe, AU - Chiodini,Paolo, AU - Panagiotakos,Demosthenes, AU - Giugliano,Dario, Y1 - 2015/08/10/ PY - 2015/8/12/entrez PY - 2015/8/12/pubmed PY - 2016/6/9/medline KW - DIABETES & ENDOCRINOLOGY KW - NUTRITION & DIETETICS KW - PREVENTIVE MEDICINE SP - e008222 EP - e008222 JF - BMJ open JO - BMJ Open VL - 5 IS - 8 N2 - OBJECTIVES: To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states. DESIGN: A systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the Mediterranean diet with a control diet on the treatment of type 2 diabetes and prediabetic states was conducted. Electronic searches were carried out up to January 2015. Trials were included for meta-analyses if they had a control group treated with another diet, if they were of sufficient duration (at least 6 months), and if they had at least 30 participants in each arm. A random-effect model was used to pool data. PARTICIPANTS: Adults with or at risk for type 2 diabetes. INTERVENTIONS: Dietary patterns that described themselves as using a 'Mediterranean' dietary pattern. OUTCOME MEASURES: The outcomes were glycaemic control, cardiovascular risk factors and remission from the metabolic syndrome. RESULTS: From 2824 studies, 8 meta-analyses and 5 RCTs were eligible. A 'de novo' meta-analysis of 3 long-term (>6 months) RCTs of the Mediterranean diet and glycaemic control of diabetes favoured the Mediterranean diet as compared with lower fat diets. Another 'de novo' meta-analysis of two long-term RCTs showed a 49% increased probability of remission from the metabolic syndrome. 5 meta-analyses showed a favourable effect of the Mediterranean diet, as compared with other diets, on body weight, total cholesterol and high-density lipoprotein cholesterol. 2 meta-analyses demonstrated that higher adherence to the Mediterranean diet reduced the risk of future diabetes by 19-23%. CONCLUSIONS: The Mediterranean diet was associated with better glycaemic control and cardiovascular risk factors than control diets, including a lower fat diet, suggesting that it is suitable for the overall management of type 2 diabetes. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/26260349/A_journey_into_a_Mediterranean_diet_and_type_2_diabetes:_a_systematic_review_with_meta_analyses_ L2 - https://bmjopen.bmj.com/lookup/pmidlookup?view=long&pmid=26260349 DB - PRIME DP - Unbound Medicine ER -