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Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population.
Pediatr Dent 1989; 11(1):37-42PD

Abstract

Disruption of the oral mucosal lining and the lack of normal defense mechanisms predispose bone marrow transplant (BMT) patients to life-threatening infections, often caused by oral flora. Chlorhexidine, used as an oral antiseptic, appears promising in limiting oral bacteria and fungi, and therefore, may decrease oral complications associated with BMT. The purpose of this study was to determine in pediatric BMT recipients if a 0.12% chlorhexidine mouthrinse, used as an adjunct to normal in-hospital oral care regimens, would decrease the severity of oral mucositis as measured by oral ulcerations, bacteremia, and length of hospital stay. Forty-seven pediatric BMT subjects were included in this double-blind study. Subjects were instructed to use 15 ml of a mouthrinse 3 times daily to be swished and gargled for 30 sec. Each subject had 7 oral sites scored for the percentage of ulcerated mucosa twice weekly until day +35 or hospital discharge or death. Blood was cultured daily during neutropenia. Additionally, the number of days from onset of cytoreduction to hospital discharge or death was recorded for each subject. Alpha was set at .05. There was no significant difference in the severity of oral ulceration between the chlorhexidine and placebo groups (P = .18). Chlorhexidine did not reduce the development of bacteremia (P greater than .5), nor did it significantly decrease the length of hospital stay (P = .68).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2626338

Citation

Raether, D, et al. "Effectiveness of Oral Chlorhexidine for Reducing Stomatitis in a Pediatric Bone Marrow Transplant Population." Pediatric Dentistry, vol. 11, no. 1, 1989, pp. 37-42.
Raether D, Walker PO, Bostrum B, et al. Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population. Pediatr Dent. 1989;11(1):37-42.
Raether, D., Walker, P. O., Bostrum, B., & Weisdorf, D. (1989). Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population. Pediatric Dentistry, 11(1), pp. 37-42.
Raether D, et al. Effectiveness of Oral Chlorhexidine for Reducing Stomatitis in a Pediatric Bone Marrow Transplant Population. Pediatr Dent. 1989;11(1):37-42. PubMed PMID: 2626338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population. AU - Raether,D, AU - Walker,P O, AU - Bostrum,B, AU - Weisdorf,D, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 37 EP - 42 JF - Pediatric dentistry JO - Pediatr Dent VL - 11 IS - 1 N2 - Disruption of the oral mucosal lining and the lack of normal defense mechanisms predispose bone marrow transplant (BMT) patients to life-threatening infections, often caused by oral flora. Chlorhexidine, used as an oral antiseptic, appears promising in limiting oral bacteria and fungi, and therefore, may decrease oral complications associated with BMT. The purpose of this study was to determine in pediatric BMT recipients if a 0.12% chlorhexidine mouthrinse, used as an adjunct to normal in-hospital oral care regimens, would decrease the severity of oral mucositis as measured by oral ulcerations, bacteremia, and length of hospital stay. Forty-seven pediatric BMT subjects were included in this double-blind study. Subjects were instructed to use 15 ml of a mouthrinse 3 times daily to be swished and gargled for 30 sec. Each subject had 7 oral sites scored for the percentage of ulcerated mucosa twice weekly until day +35 or hospital discharge or death. Blood was cultured daily during neutropenia. Additionally, the number of days from onset of cytoreduction to hospital discharge or death was recorded for each subject. Alpha was set at .05. There was no significant difference in the severity of oral ulceration between the chlorhexidine and placebo groups (P = .18). Chlorhexidine did not reduce the development of bacteremia (P greater than .5), nor did it significantly decrease the length of hospital stay (P = .68).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0164-1263 UR - https://www.unboundmedicine.com/medline/citation/2626338/Effectiveness_of_oral_chlorhexidine_for_reducing_stomatitis_in_a_pediatric_bone_marrow_transplant_population_ L2 - https://medlineplus.gov/bonemarrowtransplantation.html DB - PRIME DP - Unbound Medicine ER -