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Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies.
BMC Public Health 2015; 15:773BP

Abstract

BACKGROUND

The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men.

METHODS

We searched the PubMed, Embase, and the Cochrane Library databases for relevant articles published prior to June 2014. Among these potential included prospective studies, the different dose categories of alcohol intake were compared with the lowest alcohol intake or non-drinkers between women and men for the outcomes of major cardiovascular or total mortality.

RESULTS

We included 23 prospective studies (18 cohorts) reporting data on 489,696 individuals. The summary relative risk ratio (RRR; female to male) for total mortality was significantly increased with moderate alcohol intake compared with the lowest alcohol intake (RRR, 1.10; 95 % confidence interval [CI]: 1.00-1.21; P = 0.047); no such significance was observed with other levels of alcohol intake (low intake: RRR, 1.07; 95 % CI: 0.98-1.17; P = 0.143; heavy intake: RRR, 1.09; 95 % CI: 0.99-1.21; P = 0.084). There was no evidence of a sex difference in the relative risk for coronary disease, cardiac death, stroke, or ischemic stroke between participants with low to heavy alcohol intake compared with those who never consumed alcohol or had the lowest alcohol intake.

CONCLUSIONS

Women with moderate to heavy alcohol intake had a significantly increased risk of total mortality compared with men in multiple subpopulations. Control of alcohol intake should be considered for women, particularly for young women who may be susceptible to binge drinking.

Authors+Show Affiliations

Department of Teaching Affairs and Scientific Research, Shandong Medical College, Jinan, Shandong, China. zhengyanlinjinan@126.com.Department of Ultrasonography, Shanghai Seventh People's Hospital, Shanghai, China. lianfengno7@126.com.Department of Ultrasonography, Shanghai Seventh People's Hospital, Shanghai, China. shiqianno7@126.com.Department of Neurosurgery, Shanghai Seventh People's Hospital, Shanghai, China. zhangchino7@126.com.Department of Rehabilitation Institute, Shanghai Seventh People's Hospital, Shanghai, China. ivy_chen89@163.com.Department of Rehabilitation Institute, Shanghai Seventh People's Hospital, Shanghai, China. zhou_ly@126.com.Department of Health Statistics, Second Military Medical University, Shanghai, China. hejia63@yeah.net.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26264040

Citation

Zheng, Yan-Ling, et al. "Alcohol Intake and Associated Risk of Major Cardiovascular Outcomes in Women Compared With Men: a Systematic Review and Meta-analysis of Prospective Observational Studies." BMC Public Health, vol. 15, 2015, p. 773.
Zheng YL, Lian F, Shi Q, et al. Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies. BMC Public Health. 2015;15:773.
Zheng, Y. L., Lian, F., Shi, Q., Zhang, C., Chen, Y. W., Zhou, Y. H., & He, J. (2015). Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies. BMC Public Health, 15, p. 773. doi:10.1186/s12889-015-2081-y.
Zheng YL, et al. Alcohol Intake and Associated Risk of Major Cardiovascular Outcomes in Women Compared With Men: a Systematic Review and Meta-analysis of Prospective Observational Studies. BMC Public Health. 2015 Aug 12;15:773. PubMed PMID: 26264040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies. AU - Zheng,Yan-Ling, AU - Lian,Feng, AU - Shi,Qian, AU - Zhang,Chi, AU - Chen,Yi-Wei, AU - Zhou,Yu-Hao, AU - He,Jia, Y1 - 2015/08/12/ PY - 2014/12/24/received PY - 2015/07/22/accepted PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2016/3/15/medline SP - 773 EP - 773 JF - BMC public health JO - BMC Public Health VL - 15 N2 - BACKGROUND: The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men. METHODS: We searched the PubMed, Embase, and the Cochrane Library databases for relevant articles published prior to June 2014. Among these potential included prospective studies, the different dose categories of alcohol intake were compared with the lowest alcohol intake or non-drinkers between women and men for the outcomes of major cardiovascular or total mortality. RESULTS: We included 23 prospective studies (18 cohorts) reporting data on 489,696 individuals. The summary relative risk ratio (RRR; female to male) for total mortality was significantly increased with moderate alcohol intake compared with the lowest alcohol intake (RRR, 1.10; 95 % confidence interval [CI]: 1.00-1.21; P = 0.047); no such significance was observed with other levels of alcohol intake (low intake: RRR, 1.07; 95 % CI: 0.98-1.17; P = 0.143; heavy intake: RRR, 1.09; 95 % CI: 0.99-1.21; P = 0.084). There was no evidence of a sex difference in the relative risk for coronary disease, cardiac death, stroke, or ischemic stroke between participants with low to heavy alcohol intake compared with those who never consumed alcohol or had the lowest alcohol intake. CONCLUSIONS: Women with moderate to heavy alcohol intake had a significantly increased risk of total mortality compared with men in multiple subpopulations. Control of alcohol intake should be considered for women, particularly for young women who may be susceptible to binge drinking. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/26264040/Alcohol_intake_and_associated_risk_of_major_cardiovascular_outcomes_in_women_compared_with_men:_a_systematic_review_and_meta_analysis_of_prospective_observational_studies_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-2081-y DB - PRIME DP - Unbound Medicine ER -