TY - JOUR T1 - Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies. AU - Mollica,Adriano, AU - Costante,Roberto, AU - Akdemir,Atilla, AU - Carradori,Simone, AU - Stefanucci,Azzurra, AU - Macedonio,Giorgia, AU - Ceruso,Mariangela, AU - Supuran,Claudiu T, Y1 - 2015/08/01/ PY - 2015/05/13/received PY - 2015/07/28/revised PY - 2015/07/29/accepted PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2016/5/27/medline KW - Molecular modeling KW - Probenecid KW - Selective carbonic anhydrase IX inhibitors KW - Selective carbonic anhydrase XII inhibitors KW - Tertiary sulfonamides SP - 5311 EP - 8 JF - Bioorganic & medicinal chemistry JO - Bioorg Med Chem VL - 23 IS - 17 N2 - Novel Probenecid-based amide derivatives, incorporating different natural amino acids, were synthesized and assayed to test their effect on the human carbonic anhydrase (hCA, EC 4.2.1.1) transmembrane isoforms hCA IX and XII over the ubiquitous isoforms hCA I and II. Most of them presented a complete loss of hCA II inhibition (K(i)s > 10,000 nM) and strong inhibitory activity against hCA IX and XII in the nanomolar range with respect to the parent compound. A residual activity against hCA I was observed for some of them. These biological results have been explained by docking studies within the active sites of the four studied human carbonic anhydrases (with or without the zinc-bound water) and helped us to better comprehend the rationale behind the design of tertiary sulfonamide compounds as potent but atypical inhibitors of specific isoforms of human carbonic anhydrase. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/26264840/Exploring_new_Probenecid_based_carbonic_anhydrase_inhibitors:_Synthesis_biological_evaluation_and_docking_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(15)00650-1 DB - PRIME DP - Unbound Medicine ER -