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Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation.
BMC Ophthalmol. 2015 Aug 12; 15:100.BO

Abstract

BACKGROUND

This prospective study investigated the safety and efficacy of a therapeutic method of treating pterygium complicated with conjunctivochalasis, using pterygium excision and conjunctival autotransplantation combined with sclera fixation, followed by therapeutic contact lens application.

METHODS

Fifty-seven patients (83 eyes) diagnosed as pterygium complicated with conjunctivochalasis, at our hospital from July 2011 to June 2012, were selected. Patients were treated with pterygium excision and conjunctival autotransplantation combined with sclera fixation surgery, then therapeutic bandage contact lenses were applied. The efficacy of simultaneous surgery was evaluated based on vision changes, tear dynamics, and other complications. Histopathological changes were investigated on removed bulbar conjunctival tissue, using hematoxylin eosin (HE) and Masson's trichrome staining.

RESULTS

(1) Three months after the operation, the success of simultaneous surgery in the treatment of pterygium was 97.6 %, and the recurrence was 2.4 %. Based on subjective evaluation, the success of the simultaneous treatment of conjunctivochalasis was 95.2 %, and failure was 4.8 %. Based on objective evaluation, the success rate was 94.0 % and the recurrence rate was 6.0 %. (2) Visual acuity of the 83 eyes was significantly improved after surgery, and was statistically significant (X 2 = 10.29, P < 0.05). (3) Three months after surgery, the height and integrity of the tear meniscus, tear film break-up time, and chloramphenicol test results of the 83 eyes were significantly improved and there was a statistically significant difference (X 2 the height and integrity of tear meniscus = 147.24, X 2 tear film break-up time = 81.17, X 2 chloramphenicol test = 17.41, P < 0.01). (4) Complications after the operation such as granulation hyperplasia, constrictive fornix, oculomotor defect, and other complications were not observed. (5) Pathological observations, using HE and Masson's trichrome staining of removed bulbar conjunctival tissue, showed several pathological changes, including obvious squamous epithelial hyperplasia, parakeratosis, basal cell pigmentation, lamina propria hemorrhage, infiltration of lymphocytes, and reduction of elastic fibers and collagen fibers.

CONCLUSION

Pterygium excision and conjunctival autotransplantation, combined with sclera fixation followed by therapeutic contact lens use was safe, effective, and suitable for simultaneous treatment of pterygium complicated with conjunctivochalasis.

Authors+Show Affiliations

Department of Ophthalmology, the first affiliated hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China. xiaoyiyu134@163.com.Department of Ophthalmology, the first affiliated hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China. yujianzhan134@163.com.Department of Ophthalmology, Zhujiang hospital of southern medical university, Guangzhou, Guangdong Province, 510282, China. weiwu134134@163.com.Department of Ophthalmology, Zhujiang hospital of southern medical university, Guangzhou, Guangdong Province, 510282, China. y13750336601@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26265227

Citation

Yu, Xiao-Yi, et al. "Simultaneous Treatment of Pterygium Complicated With Conjunctivochalasis: Analysis of Pterygium Excision and Conjunctival Autotransplantation Combined With Sclera Fixation." BMC Ophthalmology, vol. 15, 2015, p. 100.
Yu XY, Jian ZY, Wu W, et al. Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. BMC Ophthalmol. 2015;15:100.
Yu, X. Y., Jian, Z. Y., Wu, W., & Lu, X. H. (2015). Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. BMC Ophthalmology, 15, 100. https://doi.org/10.1186/s12886-015-0057-4
Yu XY, et al. Simultaneous Treatment of Pterygium Complicated With Conjunctivochalasis: Analysis of Pterygium Excision and Conjunctival Autotransplantation Combined With Sclera Fixation. BMC Ophthalmol. 2015 Aug 12;15:100. PubMed PMID: 26265227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. AU - Yu,Xiao-Yi, AU - Jian,Zhan-Yu, AU - Wu,Wei, AU - Lu,Xiao-He, Y1 - 2015/08/12/ PY - 2015/01/15/received PY - 2015/06/15/accepted PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2016/2/26/medline SP - 100 EP - 100 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 15 N2 - BACKGROUND: This prospective study investigated the safety and efficacy of a therapeutic method of treating pterygium complicated with conjunctivochalasis, using pterygium excision and conjunctival autotransplantation combined with sclera fixation, followed by therapeutic contact lens application. METHODS: Fifty-seven patients (83 eyes) diagnosed as pterygium complicated with conjunctivochalasis, at our hospital from July 2011 to June 2012, were selected. Patients were treated with pterygium excision and conjunctival autotransplantation combined with sclera fixation surgery, then therapeutic bandage contact lenses were applied. The efficacy of simultaneous surgery was evaluated based on vision changes, tear dynamics, and other complications. Histopathological changes were investigated on removed bulbar conjunctival tissue, using hematoxylin eosin (HE) and Masson's trichrome staining. RESULTS: (1) Three months after the operation, the success of simultaneous surgery in the treatment of pterygium was 97.6 %, and the recurrence was 2.4 %. Based on subjective evaluation, the success of the simultaneous treatment of conjunctivochalasis was 95.2 %, and failure was 4.8 %. Based on objective evaluation, the success rate was 94.0 % and the recurrence rate was 6.0 %. (2) Visual acuity of the 83 eyes was significantly improved after surgery, and was statistically significant (X 2 = 10.29, P < 0.05). (3) Three months after surgery, the height and integrity of the tear meniscus, tear film break-up time, and chloramphenicol test results of the 83 eyes were significantly improved and there was a statistically significant difference (X 2 the height and integrity of tear meniscus = 147.24, X 2 tear film break-up time = 81.17, X 2 chloramphenicol test = 17.41, P < 0.01). (4) Complications after the operation such as granulation hyperplasia, constrictive fornix, oculomotor defect, and other complications were not observed. (5) Pathological observations, using HE and Masson's trichrome staining of removed bulbar conjunctival tissue, showed several pathological changes, including obvious squamous epithelial hyperplasia, parakeratosis, basal cell pigmentation, lamina propria hemorrhage, infiltration of lymphocytes, and reduction of elastic fibers and collagen fibers. CONCLUSION: Pterygium excision and conjunctival autotransplantation, combined with sclera fixation followed by therapeutic contact lens use was safe, effective, and suitable for simultaneous treatment of pterygium complicated with conjunctivochalasis. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/26265227/Simultaneous_treatment_of_pterygium_complicated_with_conjunctivochalasis:_analysis_of_pterygium_excision_and_conjunctival_autotransplantation_combined_with_sclera_fixation_ L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-015-0057-4 DB - PRIME DP - Unbound Medicine ER -