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Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter?
J Clin Diagn Res 2015; 9(6):UC01-4JC

Abstract

BACKGROUND

The effectiveness of fluid preloading is in doubt, so co-loading has been attempted to reduce the incidence of spinal anaesthesia induced hypotension in caesarean patients.

AIM

To compare crystalloid preloading, colloid preloading and colloid co-loading for prevention of maternal hypotension in caesarean delivery.

SETTINGS AND DESIGN

Study conducted in tertiary level hospital on 90 ASA I/II term parturients posted for elective caesarean section. Patients were randomly allocated to three Groups.

MATERIALS AND METHODS

Group A (n=30) was given 10 ml/kg of 6% hydroxyethyl starch (HES) 20 minutes prior to spinal anaesthesia, Group B (n=30) was given 10 ml/kg of 6% HES by rapid infusion in 10 minutes immediately after spinal anaesthesia and Group C (n=30) was given 10 ml/kg of Ringer's Lactate 20 minutes prior to spinal anaesthesia. Intraoperatively, Heart rate, systolic, diastolic and mean arterial pressure were recorded every five minutes. Episodes of hypotension were recorded and treated with bolus of 5 mg of ephedrine and total amount of ephedrine was noted. Adverse effects, if any were recorded.

STATISTICAL ANALYSIS

ANNOVA for Quantitative Analysis and chi-Square test and Z-test for Qualitative Analysis.

RESULTS

Baseline parameters were similar in all the three Groups. Heart rate decreased from the baseline in all the three Groups, however, mean heart rate was highest in Group C. Heart rate was statistically similar in Groups A and B. MAP decreased in all three Groups from baseline, however, highest fall was recorded in Group C whereas, MAP was statistically similar in Groups A and B. Incidence of hypotension was 66.66% in Group C as compared to 36.66% in Groups A and 40% in Group B respectively. Group C patients received 5.33±4.54 mg of ephedrine as compared to 2.00±2.82 mg in Group A and 2.33±3.14 mg in Group B. Thus, the incidence of hypotension and ephedrine consumption was significantly higher in Group C as compared to Groups A and B whereas, this difference was statistically not significant among Groups A and B.

CONCLUSION

Colloid preloading and co-loading are equally effective and both are superior to crystalloid preloading for prevention of maternal hypotension in caesarean section patients.

Authors+Show Affiliations

Senior Resident, Department of Anesthesia, AIIMS , Rishikesh, India .Professor, Department of Anesthesia, DMC & H , Ludhiana, India .Associate Professor, Department of Anesthesia, DMC & H , Ludhiana, India .Professor, Department of Anesthesia, DMC & H , Ludhiana, India .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26266190

Citation

Arora, Poonam, et al. "Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter?" Journal of Clinical and Diagnostic Research : JCDR, vol. 9, no. 6, 2015, pp. UC01-4.
Arora P, Singh RM, Kundra S, et al. Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter? J Clin Diagn Res. 2015;9(6):UC01-4.
Arora, P., Singh, R. M., Kundra, S., & Gautam, P. L. (2015). Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter? Journal of Clinical and Diagnostic Research : JCDR, 9(6), pp. UC01-4. doi:10.7860/JCDR/2015/12083.6008.
Arora P, et al. Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter. J Clin Diagn Res. 2015;9(6):UC01-4. PubMed PMID: 26266190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluid Administration Before Caesarean Delivery: Does Type and Timing Matter? AU - Arora,Poonam, AU - Singh,Rupinder M, AU - Kundra,Sandeep, AU - Gautam,Parshotam Lal, Y1 - 2015/06/01/ PY - 2014/11/12/received PY - 2015/04/06/accepted PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2015/8/13/medline KW - Co-loading KW - Crystalloids KW - Preloading SP - UC01 EP - 4 JF - Journal of clinical and diagnostic research : JCDR JO - J Clin Diagn Res VL - 9 IS - 6 N2 - BACKGROUND: The effectiveness of fluid preloading is in doubt, so co-loading has been attempted to reduce the incidence of spinal anaesthesia induced hypotension in caesarean patients. AIM: To compare crystalloid preloading, colloid preloading and colloid co-loading for prevention of maternal hypotension in caesarean delivery. SETTINGS AND DESIGN: Study conducted in tertiary level hospital on 90 ASA I/II term parturients posted for elective caesarean section. Patients were randomly allocated to three Groups. MATERIALS AND METHODS: Group A (n=30) was given 10 ml/kg of 6% hydroxyethyl starch (HES) 20 minutes prior to spinal anaesthesia, Group B (n=30) was given 10 ml/kg of 6% HES by rapid infusion in 10 minutes immediately after spinal anaesthesia and Group C (n=30) was given 10 ml/kg of Ringer's Lactate 20 minutes prior to spinal anaesthesia. Intraoperatively, Heart rate, systolic, diastolic and mean arterial pressure were recorded every five minutes. Episodes of hypotension were recorded and treated with bolus of 5 mg of ephedrine and total amount of ephedrine was noted. Adverse effects, if any were recorded. STATISTICAL ANALYSIS: ANNOVA for Quantitative Analysis and chi-Square test and Z-test for Qualitative Analysis. RESULTS: Baseline parameters were similar in all the three Groups. Heart rate decreased from the baseline in all the three Groups, however, mean heart rate was highest in Group C. Heart rate was statistically similar in Groups A and B. MAP decreased in all three Groups from baseline, however, highest fall was recorded in Group C whereas, MAP was statistically similar in Groups A and B. Incidence of hypotension was 66.66% in Group C as compared to 36.66% in Groups A and 40% in Group B respectively. Group C patients received 5.33±4.54 mg of ephedrine as compared to 2.00±2.82 mg in Group A and 2.33±3.14 mg in Group B. Thus, the incidence of hypotension and ephedrine consumption was significantly higher in Group C as compared to Groups A and B whereas, this difference was statistically not significant among Groups A and B. CONCLUSION: Colloid preloading and co-loading are equally effective and both are superior to crystalloid preloading for prevention of maternal hypotension in caesarean section patients. SN - 2249-782X UR - https://www.unboundmedicine.com/medline/citation/26266190/Fluid_Administration_Before_Caesarean_Delivery:_Does_Type_and_Timing_Matter L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26266190/ DB - PRIME DP - Unbound Medicine ER -