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Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale.
J Drugs Dermatol. 2015 Aug; 14(8):841-4.JD

Abstract

BACKGROUND

Facial erythema is a primary feature of rosacea. Currently, no validated scales exist that can accurately capture a patient's self-assessment of their own facial erythema. During phase 2 studies for brimonidine tartrate gel, a 5-point numeric rating scale was developed as a tool to allow subjects to provide an independent assessment of visible changes to the facial erythema associated with their rosacea.

OBJECTIVE

The objective of this study was to validate the revised patient's self-assessment (PSA) scale and evaluate it for statistical reliability and validity in quantification of facial erythema of rosacea.

METHODS

The validity of the PSA scale was evaluated by assessing the test-retest reliability, construct validity, and known-groups validity based on the data collected during a Phase 2b study on brimonidine gel for the treatment of persistent facial erythema of rosacea.

RESULTS

Based on the results of this evaluation, this PSA scale demonstrated test-retest reliability, construct validity, and known-groups validity.

LIMITATIONS

Study results are most generalizable to those with moderate to severe erythema.

CONCLUSION

The PSA is an appropriate scale to assess facial erythema associated with rosacea.

Authors

Tan J
No affiliation info available
Leoni M
No affiliation info available

MeSH

AdolescentAdrenergic alpha-2 Receptor AgonistsAdultBrimonidine TartrateDiagnostic Self EvaluationDouble-Blind MethodErythemaFacial DermatosesFemaleGelsHumansMaleReproducibility of ResultsRosaceaSeverity of Illness IndexYoung Adult

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

26267728

Citation

Tan, Jerry, and Matthew Leoni. "Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale." Journal of Drugs in Dermatology : JDD, vol. 14, no. 8, 2015, pp. 841-4.
Tan J, Leoni M. Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale. J Drugs Dermatol. 2015;14(8):841-4.
Tan, J., & Leoni, M. (2015). Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale. Journal of Drugs in Dermatology : JDD, 14(8), 841-4.
Tan J, Leoni M. Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale. J Drugs Dermatol. 2015;14(8):841-4. PubMed PMID: 26267728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythema of Rosacea: Validation of Patient's Self-Assessment Grading Scale. AU - Tan,Jerry, AU - Leoni,Matthew, PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2016/5/21/medline SP - 841 EP - 4 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 14 IS - 8 N2 - BACKGROUND: Facial erythema is a primary feature of rosacea. Currently, no validated scales exist that can accurately capture a patient's self-assessment of their own facial erythema. During phase 2 studies for brimonidine tartrate gel, a 5-point numeric rating scale was developed as a tool to allow subjects to provide an independent assessment of visible changes to the facial erythema associated with their rosacea. OBJECTIVE: The objective of this study was to validate the revised patient's self-assessment (PSA) scale and evaluate it for statistical reliability and validity in quantification of facial erythema of rosacea. METHODS: The validity of the PSA scale was evaluated by assessing the test-retest reliability, construct validity, and known-groups validity based on the data collected during a Phase 2b study on brimonidine gel for the treatment of persistent facial erythema of rosacea. RESULTS: Based on the results of this evaluation, this PSA scale demonstrated test-retest reliability, construct validity, and known-groups validity. LIMITATIONS: Study results are most generalizable to those with moderate to severe erythema. CONCLUSION: The PSA is an appropriate scale to assess facial erythema associated with rosacea. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/26267728/Erythema_of_Rosacea:_Validation_of_Patient's_Self_Assessment_Grading_Scale_ DB - PRIME DP - Unbound Medicine ER -