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Elevated serum fibrinogen levels and risk of contrast-induced acute kidney injury in patients undergoing a percutaneous coronary intervention for the treatment of acute coronary syndrome.
Coron Artery Dis 2016; 27(1):13-8CA

Abstract

OBJECTIVES

Contrast-induced acute kidney injury (CI-AKI) is a common complication of diagnostic and therapeutic catheterizations, especially in the setting of acute coronary syndrome (ACS). Fibrinogen is a well-known cardiovascular risk factor. We evaluated whether serum fibrinogen level is associated independently with CI-AKI in patients with ACS who underwent a percutaneous coronary intervention (PCI).

METHODS

Patients (n=710, aged 61 ± 13, 69% men) were classified into two groups: CI-AKI and non-CI-AKI. CI-AKI was defined as an increase of at least 0.5 mg/dl or at least 25% in the serum creatinine level within 72 h following PCI.

RESULTS

CI-AKI occurred in 75 (10.6%) patients. We found significantly higher serum fibrinogen levels in patients who developed CI-AKI than in those who did not (498 ± 152 vs. 386 ± 96 mg/dl, P<0.001). Multivariate logistic regression analysis showed that serum fibrinogen level (odds ratio 1.006, 95% confidence interval 1.003-1.009, P<0.001), age, glomerular filtration rate, female sex, and white blood cell count were correlated with the development of CI-AKI.

CONCLUSION

Serum fibrinogen level is associated independently with a higher risk of CI-AKI in patients with ACS undergoing PCI.

Authors+Show Affiliations

Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26267748

Citation

Celik, Ibrahim E., et al. "Elevated Serum Fibrinogen Levels and Risk of Contrast-induced Acute Kidney Injury in Patients Undergoing a Percutaneous Coronary Intervention for the Treatment of Acute Coronary Syndrome." Coronary Artery Disease, vol. 27, no. 1, 2016, pp. 13-8.
Celik IE, Kurtul A, Duran M, et al. Elevated serum fibrinogen levels and risk of contrast-induced acute kidney injury in patients undergoing a percutaneous coronary intervention for the treatment of acute coronary syndrome. Coron Artery Dis. 2016;27(1):13-8.
Celik, I. E., Kurtul, A., Duran, M., Yarlioglues, M., Elcik, D., Kilic, A., ... Murat, S. N. (2016). Elevated serum fibrinogen levels and risk of contrast-induced acute kidney injury in patients undergoing a percutaneous coronary intervention for the treatment of acute coronary syndrome. Coronary Artery Disease, 27(1), pp. 13-8. doi:10.1097/MCA.0000000000000295.
Celik IE, et al. Elevated Serum Fibrinogen Levels and Risk of Contrast-induced Acute Kidney Injury in Patients Undergoing a Percutaneous Coronary Intervention for the Treatment of Acute Coronary Syndrome. Coron Artery Dis. 2016;27(1):13-8. PubMed PMID: 26267748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum fibrinogen levels and risk of contrast-induced acute kidney injury in patients undergoing a percutaneous coronary intervention for the treatment of acute coronary syndrome. AU - Celik,Ibrahim E, AU - Kurtul,Alparslan, AU - Duran,Mustafa, AU - Yarlioglues,Mikail, AU - Elcik,Deniz, AU - Kilic,Alparslan, AU - Koseoglu,Cemal, AU - Oksuz,Fatih, AU - Murat,Sani N, PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2016/9/24/medline SP - 13 EP - 8 JF - Coronary artery disease JO - Coron. Artery Dis. VL - 27 IS - 1 N2 - OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is a common complication of diagnostic and therapeutic catheterizations, especially in the setting of acute coronary syndrome (ACS). Fibrinogen is a well-known cardiovascular risk factor. We evaluated whether serum fibrinogen level is associated independently with CI-AKI in patients with ACS who underwent a percutaneous coronary intervention (PCI). METHODS: Patients (n=710, aged 61 ± 13, 69% men) were classified into two groups: CI-AKI and non-CI-AKI. CI-AKI was defined as an increase of at least 0.5 mg/dl or at least 25% in the serum creatinine level within 72 h following PCI. RESULTS: CI-AKI occurred in 75 (10.6%) patients. We found significantly higher serum fibrinogen levels in patients who developed CI-AKI than in those who did not (498 ± 152 vs. 386 ± 96 mg/dl, P<0.001). Multivariate logistic regression analysis showed that serum fibrinogen level (odds ratio 1.006, 95% confidence interval 1.003-1.009, P<0.001), age, glomerular filtration rate, female sex, and white blood cell count were correlated with the development of CI-AKI. CONCLUSION: Serum fibrinogen level is associated independently with a higher risk of CI-AKI in patients with ACS undergoing PCI. SN - 1473-5830 UR - https://www.unboundmedicine.com/medline/citation/26267748/Elevated_serum_fibrinogen_levels_and_risk_of_contrast_induced_acute_kidney_injury_in_patients_undergoing_a_percutaneous_coronary_intervention_for_the_treatment_of_acute_coronary_syndrome_ L2 - http://dx.doi.org/10.1097/MCA.0000000000000295 DB - PRIME DP - Unbound Medicine ER -