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Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate.
Laryngoscope. 2016 06; 126(6):1475-80.L

Abstract

OBJECTIVES/HYPOTHESIS

Children with cleft lip and palate (CLP) often suffer from nasal obstruction that may be related to effects on nasal volume. The objective of this study was to compare side:side volume ratios and nasal volume in patients with unilateral (UCLP) and bilateral (BCLP) clefts with age-matched controls.

STUDY DESIGN

Retrospective case-control study using three-dimensional (3D) nasal airway reconstructions.

METHODS

We analyzed 20 subjects (age range = 7-12 years) with UCLP and BCLP from a regional craniofacial center who underwent cone beam computed tomography (CT) prior to alveolar grafting. Ten multislice CT images from age-matched controls were also analyzed. Mimics software (Materialise, Plymouth, MI) was used to create 3D reconstructions of the main nasal cavity and compute total and side-specific nasal volumes. Subjects imaged during active nasal cycling phases were excluded.

RESULTS

There was no statistically significant difference in affected:unaffected side volume ratios in UCLP (P = .48) or left:right ratios in BCLP (P = .25) when compared to left:right ratios in controls. Mean overall nasal volumes were 9,932 ± 1,807, 7,097 ± 2,596, and 6,715 ± 2,115 mm(3) for control, UCLP, and BCLP patients, respectively, with statistically significant volume decreases for both UCLP and BCLP subjects from controls (P < .05).

CONCLUSIONS

This is the first study to analyze total nasal volumes in BCLP patients. Overall nasal volume is compromised in UCLP and BCLP by approximately 30%. Additionally, our finding of no major difference in side:side ratios in UCLP and BCLP compared to controls conflicts with pre-existing literature, likely due to exclusion of actively cycling scans and our measurement of the functional nasal cavity.

LEVEL OF EVIDENCE

3b. Laryngoscope, 126:1475-1480, 2016.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.Department of Oral Diagnosis, Division of Radiology, Piracicaba Dental School, University of Campinas, Campinas, Brazil.Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.Department of Pediatrics, Section of Pediatric Pulmonology, Allergy, and Sleep Medicine, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, Indiana, U.S.A.Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.University of North Carolina Craniofacial Center, Chapel Hill, North Carolina, U.S.A.Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A. University of North Carolina Craniofacial Center, Chapel Hill, North Carolina, U.S.A.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26267849

Citation

Farzal, Zainab, et al. "Volumetric Nasal Cavity Analysis in Children With Unilateral and Bilateral Cleft Lip and Palate." The Laryngoscope, vol. 126, no. 6, 2016, pp. 1475-80.
Farzal Z, Walsh J, Lopes de Rezende Barbosa G, et al. Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. Laryngoscope. 2016;126(6):1475-80.
Farzal, Z., Walsh, J., Lopes de Rezende Barbosa, G., Zdanski, C. J., Davis, S. D., Superfine, R., Pimenta, L. A., Kimbell, J. S., & Drake, A. F. (2016). Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. The Laryngoscope, 126(6), 1475-80. https://doi.org/10.1002/lary.25543
Farzal Z, et al. Volumetric Nasal Cavity Analysis in Children With Unilateral and Bilateral Cleft Lip and Palate. Laryngoscope. 2016;126(6):1475-80. PubMed PMID: 26267849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. AU - Farzal,Zainab, AU - Walsh,Jonathan, AU - Lopes de Rezende Barbosa,Gabriella, AU - Zdanski,Carlton J, AU - Davis,Stephanie D, AU - Superfine,Richard, AU - Pimenta,Luiz A, AU - Kimbell,Julia S, AU - Drake,Amelia Fischer, Y1 - 2015/08/12/ PY - 2015/04/02/received PY - 2015/06/09/revised PY - 2015/07/06/accepted PY - 2015/8/13/entrez PY - 2015/8/13/pubmed PY - 2017/8/5/medline KW - Nasal volume KW - bilateral cleft lip and palate KW - unilateral cleft lip and palate SP - 1475 EP - 80 JF - The Laryngoscope JO - Laryngoscope VL - 126 IS - 6 N2 - OBJECTIVES/HYPOTHESIS: Children with cleft lip and palate (CLP) often suffer from nasal obstruction that may be related to effects on nasal volume. The objective of this study was to compare side:side volume ratios and nasal volume in patients with unilateral (UCLP) and bilateral (BCLP) clefts with age-matched controls. STUDY DESIGN: Retrospective case-control study using three-dimensional (3D) nasal airway reconstructions. METHODS: We analyzed 20 subjects (age range = 7-12 years) with UCLP and BCLP from a regional craniofacial center who underwent cone beam computed tomography (CT) prior to alveolar grafting. Ten multislice CT images from age-matched controls were also analyzed. Mimics software (Materialise, Plymouth, MI) was used to create 3D reconstructions of the main nasal cavity and compute total and side-specific nasal volumes. Subjects imaged during active nasal cycling phases were excluded. RESULTS: There was no statistically significant difference in affected:unaffected side volume ratios in UCLP (P = .48) or left:right ratios in BCLP (P = .25) when compared to left:right ratios in controls. Mean overall nasal volumes were 9,932 ± 1,807, 7,097 ± 2,596, and 6,715 ± 2,115 mm(3) for control, UCLP, and BCLP patients, respectively, with statistically significant volume decreases for both UCLP and BCLP subjects from controls (P < .05). CONCLUSIONS: This is the first study to analyze total nasal volumes in BCLP patients. Overall nasal volume is compromised in UCLP and BCLP by approximately 30%. Additionally, our finding of no major difference in side:side ratios in UCLP and BCLP compared to controls conflicts with pre-existing literature, likely due to exclusion of actively cycling scans and our measurement of the functional nasal cavity. LEVEL OF EVIDENCE: 3b. Laryngoscope, 126:1475-1480, 2016. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/26267849/Volumetric_nasal_cavity_analysis_in_children_with_unilateral_and_bilateral_cleft_lip_and_palate_ L2 - https://doi.org/10.1002/lary.25543 DB - PRIME DP - Unbound Medicine ER -