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Oral provocation tests with aspirin and food additives in asthmatic patients.
Yonsei Med J. 1989 Dec; 30(4):339-45.YM

Abstract

Aspirin and food additives are known to induce bronchoconstriction, angioedema or urticaria in susceptible patients. To evaluate the incidence of hypersensitivity to aspirin and food additives, 36 subjects with bronchial asthma, 33 of whom were non-allergic asthmatics and 3 were allergic asthmatics who had a history of aspirin sensitivity, were challenged orally with six compounds: acetylsalicylic acid (ASA), sodium bisulfite, tartrazine, sodium benzoate, 4-hydroxy benzoic acid, and monosodium L-glutamate. Significant bronchoconstrictions were found in 15 (41.7%) of the 36 subjects tested. Eight of the 15 subjects showed positive asthmatic responses to the aspirin, two showed asthmatic responses to the food additives, and five responded to both aspirin and the food additives. It is suggested that ASA and food additives could be causes of clinically significant bronchoconstriction in moderately severe non-allergic asthmatic patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2626838

Citation

Hong, S P., et al. "Oral Provocation Tests With Aspirin and Food Additives in Asthmatic Patients." Yonsei Medical Journal, vol. 30, no. 4, 1989, pp. 339-45.
Hong SP, Park HS, Lee MK, et al. Oral provocation tests with aspirin and food additives in asthmatic patients. Yonsei Med J. 1989;30(4):339-45.
Hong, S. P., Park, H. S., Lee, M. K., & Hong, C. S. (1989). Oral provocation tests with aspirin and food additives in asthmatic patients. Yonsei Medical Journal, 30(4), 339-45.
Hong SP, et al. Oral Provocation Tests With Aspirin and Food Additives in Asthmatic Patients. Yonsei Med J. 1989;30(4):339-45. PubMed PMID: 2626838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral provocation tests with aspirin and food additives in asthmatic patients. AU - Hong,S P, AU - Park,H S, AU - Lee,M K, AU - Hong,C S, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 339 EP - 45 JF - Yonsei medical journal JO - Yonsei Med J VL - 30 IS - 4 N2 - Aspirin and food additives are known to induce bronchoconstriction, angioedema or urticaria in susceptible patients. To evaluate the incidence of hypersensitivity to aspirin and food additives, 36 subjects with bronchial asthma, 33 of whom were non-allergic asthmatics and 3 were allergic asthmatics who had a history of aspirin sensitivity, were challenged orally with six compounds: acetylsalicylic acid (ASA), sodium bisulfite, tartrazine, sodium benzoate, 4-hydroxy benzoic acid, and monosodium L-glutamate. Significant bronchoconstrictions were found in 15 (41.7%) of the 36 subjects tested. Eight of the 15 subjects showed positive asthmatic responses to the aspirin, two showed asthmatic responses to the food additives, and five responded to both aspirin and the food additives. It is suggested that ASA and food additives could be causes of clinically significant bronchoconstriction in moderately severe non-allergic asthmatic patients. SN - 0513-5796 UR - https://www.unboundmedicine.com/medline/citation/2626838/Oral_provocation_tests_with_aspirin_and_food_additives_in_asthmatic_patients_ L2 - https://www.eymj.org/DOIx.php?id=10.3349/ymj.1989.30.4.339 DB - PRIME DP - Unbound Medicine ER -