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Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis.
World J Gastroenterol. 2015 Aug 07; 21(29):8868-77.WJ

Abstract

AIM

To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis.

METHODS

We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a meta-analysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis.

RESULTS

In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma (OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95%CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia.

CONCLUSION

These data suggest an inverse association between circulating 25(OH)D levels and colorectal adenoma in both Western and Asian populations.

Authors+Show Affiliations

Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.Yoon Ji Choi, Young Ha Kim, Jung Eun Lee, Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26269676

Citation

Choi, Yoon Ji, et al. "Circulating Levels of Vitamin D and Colorectal Adenoma: a Case-control Study and a Meta-analysis." World Journal of Gastroenterology, vol. 21, no. 29, 2015, pp. 8868-77.
Choi YJ, Kim YH, Cho CH, et al. Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis. World J Gastroenterol. 2015;21(29):8868-77.
Choi, Y. J., Kim, Y. H., Cho, C. H., Kim, S. H., & Lee, J. E. (2015). Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis. World Journal of Gastroenterology, 21(29), 8868-77. https://doi.org/10.3748/wjg.v21.i29.8868
Choi YJ, et al. Circulating Levels of Vitamin D and Colorectal Adenoma: a Case-control Study and a Meta-analysis. World J Gastroenterol. 2015 Aug 7;21(29):8868-77. PubMed PMID: 26269676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis. AU - Choi,Yoon Ji, AU - Kim,Young Ha, AU - Cho,Chang Ho, AU - Kim,Sung Hi, AU - Lee,Jung Eun, PY - 2015/02/28/received PY - 2015/05/19/revised PY - 2015/06/10/accepted PY - 2015/8/14/entrez PY - 2015/8/14/pubmed PY - 2016/10/7/medline KW - 25-hydroxyvitamin D levels KW - Cancer prevention KW - Colorectal adenoma SP - 8868 EP - 77 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 21 IS - 29 N2 - AIM: To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis. METHODS: We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a meta-analysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. RESULTS: In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma (OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95%CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia. CONCLUSION: These data suggest an inverse association between circulating 25(OH)D levels and colorectal adenoma in both Western and Asian populations. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26269676/Circulating_levels_of_vitamin_D_and_colorectal_adenoma:_A_case_control_study_and_a_meta_analysis_ L2 - http://www.wjgnet.com/1007-9327/full/v21/i29/8868.htm DB - PRIME DP - Unbound Medicine ER -