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Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors.
J Diabetes Res. 2015; 2015:783296.JD

Abstract

OBJECTIVE

To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors.

METHODS

In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses.

RESULTS

Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR.

CONCLUSIONS

In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.

Authors+Show Affiliations

Institute of Nutrition and Food Technology, University of Chile, Avenida El Líbano 5524, Macul, 7840390 Santiago, Chile.Institute of Nutrition and Food Technology, University of Chile, Avenida El Líbano 5524, Macul, 7840390 Santiago, Chile.Institute of Nutrition and Food Technology, University of Chile, Avenida El Líbano 5524, Macul, 7840390 Santiago, Chile.Division of Child Development and Community Health, University of California, San Diego, 9500 Gilman Drive, MC 0927, La Jolla, San Diego, CA 92093-0927, USA.Institute of Nutrition and Food Technology, University of Chile, Avenida El Líbano 5524, Macul, 7840390 Santiago, Chile.Division of Child Development and Community Health, University of California, San Diego, 9500 Gilman Drive, MC 0927, La Jolla, San Diego, CA 92093-0927, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26273675

Citation

Burrows, R, et al. "Healthy Chilean Adolescents With HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association With Genetic, Biological, and Environmental Factors." Journal of Diabetes Research, vol. 2015, 2015, p. 783296.
Burrows R, Correa-Burrows P, Reyes M, et al. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. J Diabetes Res. 2015;2015:783296.
Burrows, R., Correa-Burrows, P., Reyes, M., Blanco, E., Albala, C., & Gahagan, S. (2015). Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research, 2015, 783296. https://doi.org/10.1155/2015/783296
Burrows R, et al. Healthy Chilean Adolescents With HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association With Genetic, Biological, and Environmental Factors. J Diabetes Res. 2015;2015:783296. PubMed PMID: 26273675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. AU - Burrows,R, AU - Correa-Burrows,P, AU - Reyes,M, AU - Blanco,E, AU - Albala,C, AU - Gahagan,S, Y1 - 2015/07/27/ PY - 2014/11/24/received PY - 2015/01/06/revised PY - 2015/01/07/accepted PY - 2015/8/15/entrez PY - 2015/8/15/pubmed PY - 2016/8/16/medline SP - 783296 EP - 783296 JF - Journal of diabetes research JO - J Diabetes Res VL - 2015 N2 - OBJECTIVE: To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors. METHODS: In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses. RESULTS: Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR. CONCLUSIONS: In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk. SN - 2314-6753 UR - https://www.unboundmedicine.com/medline/citation/26273675/Healthy_Chilean_Adolescents_with_HOMA_IR_≥_2_6_Have_Increased_Cardiometabolic_Risk:_Association_with_Genetic_Biological_and_Environmental_Factors_ L2 - https://doi.org/10.1155/2015/783296 DB - PRIME DP - Unbound Medicine ER -