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Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats.
Behav Pharmacol. 2016 Feb; 27(1):29-36.BP

Abstract

A sensitive response of the nervous system to changes in temperature is of predominant importance for homeotherms to maintain a stable body temperature. A number of temperature-sensitive transient receptor potential (TRP) ion channels have been studied as nociceptors that respond to extreme temperatures and harmful chemicals. Recent findings in the field of pain have established a family of six thermo-TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, and TRPV4) that exhibit sensitivity to increases or decreases in temperature, as well as to chemical substances eliciting the respective hot or cold sensations. In this study, we used behavioral methods to investigate whether mustard oil (allyl isothiocyanate) and capsaicin affect the sensitivity to heat, innocuous and noxious cold, and mechanical stimuli in male rats. The results obtained indicate that TRPA1 and TRPV1 channels are clearly involved in pain reactions, and the TRPA1 agonist allyl isothiocyanate enhances the heat pain sensitivity, possibly by indirectly modulating TRPV1 channels coexpressed in nociceptors with TRPA1. Overall, our data support the role of thermosensitive TRPA1 and TRPV1 channels in pain modulation and show that these two thermoreceptor channels are in a synergistic and/or conditional relationship with noxious heat and cold cutaneous stimulation.

Authors+Show Affiliations

Department of Neurophysiology, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26274042

Citation

Nozadze, Ivliane, et al. "Role of Thermo TRPA1 and TRPV1 Channels in Heat, Cold, and Mechanical Nociception of Rats." Behavioural Pharmacology, vol. 27, no. 1, 2016, pp. 29-36.
Nozadze I, Tsiklauri N, Gurtskaia G, et al. Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats. Behav Pharmacol. 2016;27(1):29-36.
Nozadze, I., Tsiklauri, N., Gurtskaia, G., & Tsagareli, M. G. (2016). Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats. Behavioural Pharmacology, 27(1), 29-36. https://doi.org/10.1097/FBP.0000000000000176
Nozadze I, et al. Role of Thermo TRPA1 and TRPV1 Channels in Heat, Cold, and Mechanical Nociception of Rats. Behav Pharmacol. 2016;27(1):29-36. PubMed PMID: 26274042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats. AU - Nozadze,Ivliane, AU - Tsiklauri,Nana, AU - Gurtskaia,Gulnazi, AU - Tsagareli,Merab G, PY - 2015/8/15/entrez PY - 2015/8/15/pubmed PY - 2016/9/20/medline SP - 29 EP - 36 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 27 IS - 1 N2 - A sensitive response of the nervous system to changes in temperature is of predominant importance for homeotherms to maintain a stable body temperature. A number of temperature-sensitive transient receptor potential (TRP) ion channels have been studied as nociceptors that respond to extreme temperatures and harmful chemicals. Recent findings in the field of pain have established a family of six thermo-TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, and TRPV4) that exhibit sensitivity to increases or decreases in temperature, as well as to chemical substances eliciting the respective hot or cold sensations. In this study, we used behavioral methods to investigate whether mustard oil (allyl isothiocyanate) and capsaicin affect the sensitivity to heat, innocuous and noxious cold, and mechanical stimuli in male rats. The results obtained indicate that TRPA1 and TRPV1 channels are clearly involved in pain reactions, and the TRPA1 agonist allyl isothiocyanate enhances the heat pain sensitivity, possibly by indirectly modulating TRPV1 channels coexpressed in nociceptors with TRPA1. Overall, our data support the role of thermosensitive TRPA1 and TRPV1 channels in pain modulation and show that these two thermoreceptor channels are in a synergistic and/or conditional relationship with noxious heat and cold cutaneous stimulation. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/26274042/Role_of_thermo_TRPA1_and_TRPV1_channels_in_heat_cold_and_mechanical_nociception_of_rats_ L2 - https://doi.org/10.1097/FBP.0000000000000176 DB - PRIME DP - Unbound Medicine ER -