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Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study.
Nutrients 2015; 7(8):6739-50N

Abstract

Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = -0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = -0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.

Authors+Show Affiliations

Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. justine.chouet@gmail.com.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. guylaine.ferland@umontreal.ca.Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France. catherine.feart@isped.u-bordeaux2.fr. INSERM, ISPED, INSERM_U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France. catherine.feart@isped.u-bordeaux2.fr.Department of Geriatric Medicine, Institut du Vieillissement, University Hospital INSERM U1027, Toulouse F-31400, France. rolland.y@chu-toulouse.fr.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. nancy.presse@umontreal.ca.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada. kariane.boucher@gmail.com.Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France. INSERM, ISPED, INSERM_U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France.Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. OlBeauchet@chu-angers.fr.Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France. CeAnnweiler@chu-angers.fr. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 5B7, Canada. CeAnnweiler@chu-angers.fr.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

26274973

Citation

Chouet, Justine, et al. "Dietary Vitamin K Intake Is Associated With Cognition and Behaviour Among Geriatric Patients: the CLIP Study." Nutrients, vol. 7, no. 8, 2015, pp. 6739-50.
Chouet J, Ferland G, Féart C, et al. Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. Nutrients. 2015;7(8):6739-50.
Chouet, J., Ferland, G., Féart, C., Rolland, Y., Presse, N., Boucher, K., ... Annweiler, C. (2015). Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. Nutrients, 7(8), pp. 6739-50. doi:10.3390/nu7085306.
Chouet J, et al. Dietary Vitamin K Intake Is Associated With Cognition and Behaviour Among Geriatric Patients: the CLIP Study. Nutrients. 2015 Aug 12;7(8):6739-50. PubMed PMID: 26274973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. AU - Chouet,Justine, AU - Ferland,Guylaine, AU - Féart,Catherine, AU - Rolland,Yves, AU - Presse,Nancy, AU - Boucher,Kariane, AU - Barberger-Gateau,Pascale, AU - Beauchet,Olivier, AU - Annweiler,Cedric, Y1 - 2015/08/12/ PY - 2015/06/15/received PY - 2015/07/16/revised PY - 2015/07/24/accepted PY - 2015/8/15/entrez PY - 2015/8/15/pubmed PY - 2016/5/20/medline KW - behavior KW - cognition KW - diet KW - older adults KW - vitamin K SP - 6739 EP - 50 JF - Nutrients JO - Nutrients VL - 7 IS - 8 N2 - Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = -0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = -0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26274973/Dietary_Vitamin_K_Intake_Is_Associated_with_Cognition_and_Behaviour_among_Geriatric_Patients:_The_CLIP_Study_ L2 - http://www.mdpi.com/resolver?pii=nu7085306 DB - PRIME DP - Unbound Medicine ER -