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Pectin/anhydrous dibasic calcium phosphate matrix tablets for in vitro controlled release of water-soluble drug.
Int J Pharm. 2015 Oct 15; 494(1):235-43.IJ

Abstract

Different pectin/anhydrous dibasic calcium phosphate (ADCP) matrix tablets have been developed in order to obtain controlled release of a water-soluble drug (theophylline). Swelling, buoyancy and dissolution studies have been carried out in different aqueous media (demineralized water, progressive pH medium, simulated gastric fluid, simulated intestinal fluid and simulated colonic fluid), to characterize the matrix tablets. When the pectin/ADCP ratio was ≥0.26 (P1, P2, P3 and P4 tablets) a continuous swelling and low theophylline dissolution rate from the matrices were observed. So, pectin gel forming feature predominated over the ADCP properties, yielding pH-independent drug release behavior from these matrices. On the contrary, pectin/ADCP ratios ≤0.11 (P5 and P6 tablets) allowed to achieve drug dissolution pH dependent. Consequently, the suitable selection of the pectin/ADCP ratio will allow to tailor matrix tablets for controlled release of water-soluble drugs in a specific manner in the gastrointestinal tract.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mamani PL
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: nicte_1906@yahoo.es.
Ruiz-Caro R
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; Biotransformations Group, Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: rruizcar@ucm.es.
Veiga MD
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; Biotransformations Group, Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: mdveiga@ucm.es.

MeSH

Body FluidsCalcium PhosphatesChemistry, PharmaceuticalDelayed-Action PreparationsDrug LiberationHydrogen-Ion ConcentrationPectinsSolubilityTabletsTheophylline

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26276258

Citation

Mamani, Pseidy Luz, et al. "Pectin/anhydrous Dibasic Calcium Phosphate Matrix Tablets for in Vitro Controlled Release of Water-soluble Drug." International Journal of Pharmaceutics, vol. 494, no. 1, 2015, pp. 235-43.
Mamani PL, Ruiz-Caro R, Veiga MD. Pectin/anhydrous dibasic calcium phosphate matrix tablets for in vitro controlled release of water-soluble drug. Int J Pharm. 2015;494(1):235-43.
Mamani, P. L., Ruiz-Caro, R., & Veiga, M. D. (2015). Pectin/anhydrous dibasic calcium phosphate matrix tablets for in vitro controlled release of water-soluble drug. International Journal of Pharmaceutics, 494(1), 235-43. https://doi.org/10.1016/j.ijpharm.2015.08.027
Mamani PL, Ruiz-Caro R, Veiga MD. Pectin/anhydrous Dibasic Calcium Phosphate Matrix Tablets for in Vitro Controlled Release of Water-soluble Drug. Int J Pharm. 2015 Oct 15;494(1):235-43. PubMed PMID: 26276258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pectin/anhydrous dibasic calcium phosphate matrix tablets for in vitro controlled release of water-soluble drug. AU - Mamani,Pseidy Luz, AU - Ruiz-Caro,Roberto, AU - Veiga,María Dolores, Y1 - 2015/08/11/ PY - 2015/06/01/received PY - 2015/08/06/revised PY - 2015/08/08/accepted PY - 2015/8/16/entrez PY - 2015/8/16/pubmed PY - 2016/9/7/medline KW - Biodegradable polymers KW - Colonic drug delivery KW - Controlled release KW - Mathematical models KW - Polymeric drug delivery systems KW - Tableting KW - Water sorption SP - 235 EP - 43 JF - International journal of pharmaceutics JO - Int J Pharm VL - 494 IS - 1 N2 - Different pectin/anhydrous dibasic calcium phosphate (ADCP) matrix tablets have been developed in order to obtain controlled release of a water-soluble drug (theophylline). Swelling, buoyancy and dissolution studies have been carried out in different aqueous media (demineralized water, progressive pH medium, simulated gastric fluid, simulated intestinal fluid and simulated colonic fluid), to characterize the matrix tablets. When the pectin/ADCP ratio was ≥0.26 (P1, P2, P3 and P4 tablets) a continuous swelling and low theophylline dissolution rate from the matrices were observed. So, pectin gel forming feature predominated over the ADCP properties, yielding pH-independent drug release behavior from these matrices. On the contrary, pectin/ADCP ratios ≤0.11 (P5 and P6 tablets) allowed to achieve drug dissolution pH dependent. Consequently, the suitable selection of the pectin/ADCP ratio will allow to tailor matrix tablets for controlled release of water-soluble drugs in a specific manner in the gastrointestinal tract. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/26276258/Pectin/anhydrous_dibasic_calcium_phosphate_matrix_tablets_for_in_vitro_controlled_release_of_water_soluble_drug_ DB - PRIME DP - Unbound Medicine ER -