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A flexible-dose dispenser for immediate and extended release 3D printed tablets.
Eur J Pharm Biopharm. 2015 Oct; 96:380-7.EJ

Abstract

The advances in personalised medicine increased the demand for a fast, accurate and reliable production method of tablets that can be digitally controlled by healthcare staff. A flexible dose tablet system is presented in this study that proved to be suitable for immediate and extended release tablets with a realistic drug loading and an easy-to-swallow tablet design. The method bridges the affordable and digitally controlled Fused Deposition Modelling (FDM) 3D printing with a standard pharmaceutical manufacturing process, Hot Melt Extrusion (HME). The reported method was compatible with three methacrylic polymers (Eudragit RL, RS and E) as well as a cellulose-based one (hydroxypropyl cellulose, HPC SSL). The use of a HME based pharmaceutical filament preserved the linear relationship between the mass and printed volume and was utilized to digitally control the dose via an input from computer software with dose accuracy in the range of 91-95%. Higher resolution printing quality doubled the printing time, but showed a little effect on in vitro release pattern of theophylline and weight accuracy. Physical characterization studies indicated that the majority of the model drug (theophylline) in the 3D printed tablet exists in a crystal form. Owing to the small size, ease of use and the highly adjustable nature of FDM 3D printers, the method holds promise for future individualised treatment.

Authors+Show Affiliations

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, UK; Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, UK.School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, UK. Electronic address: MAlbedAlhnan@uclan.ac.uk.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26277660

Citation

Pietrzak, Katarzyna, et al. "A Flexible-dose Dispenser for Immediate and Extended Release 3D Printed Tablets." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 96, 2015, pp. 380-7.
Pietrzak K, Isreb A, Alhnan MA. A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur J Pharm Biopharm. 2015;96:380-7.
Pietrzak, K., Isreb, A., & Alhnan, M. A. (2015). A flexible-dose dispenser for immediate and extended release 3D printed tablets. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 96, 380-7. https://doi.org/10.1016/j.ejpb.2015.07.027
Pietrzak K, Isreb A, Alhnan MA. A Flexible-dose Dispenser for Immediate and Extended Release 3D Printed Tablets. Eur J Pharm Biopharm. 2015;96:380-7. PubMed PMID: 26277660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A flexible-dose dispenser for immediate and extended release 3D printed tablets. AU - Pietrzak,Katarzyna, AU - Isreb,Abdullah, AU - Alhnan,Mohamed A, Y1 - 2015/08/12/ PY - 2015/04/29/received PY - 2015/07/14/revised PY - 2015/07/24/accepted PY - 2015/8/17/entrez PY - 2015/8/19/pubmed PY - 2016/8/23/medline KW - Additive manufacturing KW - FFF KW - Fused filament fabrication KW - Patient-specific KW - Personalised KW - Rapid prototyping KW - Three-dimensional printing SP - 380 EP - 7 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 96 N2 - The advances in personalised medicine increased the demand for a fast, accurate and reliable production method of tablets that can be digitally controlled by healthcare staff. A flexible dose tablet system is presented in this study that proved to be suitable for immediate and extended release tablets with a realistic drug loading and an easy-to-swallow tablet design. The method bridges the affordable and digitally controlled Fused Deposition Modelling (FDM) 3D printing with a standard pharmaceutical manufacturing process, Hot Melt Extrusion (HME). The reported method was compatible with three methacrylic polymers (Eudragit RL, RS and E) as well as a cellulose-based one (hydroxypropyl cellulose, HPC SSL). The use of a HME based pharmaceutical filament preserved the linear relationship between the mass and printed volume and was utilized to digitally control the dose via an input from computer software with dose accuracy in the range of 91-95%. Higher resolution printing quality doubled the printing time, but showed a little effect on in vitro release pattern of theophylline and weight accuracy. Physical characterization studies indicated that the majority of the model drug (theophylline) in the 3D printed tablet exists in a crystal form. Owing to the small size, ease of use and the highly adjustable nature of FDM 3D printers, the method holds promise for future individualised treatment. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/26277660/A_flexible_dose_dispenser_for_immediate_and_extended_release_3D_printed_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(15)00330-6 DB - PRIME DP - Unbound Medicine ER -