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Maxillary gap at 11-13 weeks' gestation: marker of cleft lip and palate.
Ultrasound Obstet Gynecol. 2015 Dec; 46(6):665-9.UO

Abstract

OBJECTIVE

To describe a new sign of cleft lip and palate (CLP), the maxillary gap, which is visible in the mid-sagittal plane of the fetal face used routinely for measurement of nuchal translucency thickness.

METHODS

This was a retrospective study of stored images of the mid-sagittal view of the fetal face at 11-13 weeks' gestation in 86 cases of CLP and 86 normal controls. The images were examined to determine if a maxillary gap was present, in which case its size was measured.

RESULTS

In 37 (43.0%) cases of CLP the defect was isolated and in 49 (57.0%) there were additional fetal defects. In the isolated CLP group, the diagnosis of facial cleft was made in the first trimester in nine (24.3%) cases and in the second trimester in 28 (75.7%). In the group with additional defects, the diagnosis of facial cleft was made in the first trimester in 46 (93.9%) cases and in the second trimester in three (6.1%). A maxillary gap was observed in 96% of cases of CLP with additional defects, in 65% of those with isolated CLP and in 7% of normal fetuses. There was a large gap (>1.5 mm) or complete absence of signals from the maxilla in the midline in 69% of cases of CLP with additional defects, in 35% of those with isolated CLP and in none of the normal controls.

CONCLUSIONS

The maxillary gap is a new simple marker of possible CLP, which could increase the detection rate of CLP, especially in isolated cases.

Authors+Show Affiliations

Center for Prenatal Diagnosis and Human Genetics, Berlin, Germany.Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.Center for Prenatal Diagnosis and Human Genetics, Berlin, Germany.Center for Prenatal Diagnosis and Human Genetics, Berlin, Germany.Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26277990

Citation

Chaoui, R, et al. "Maxillary Gap at 11-13 Weeks' Gestation: Marker of Cleft Lip and Palate." Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 46, no. 6, 2015, pp. 665-9.
Chaoui R, Orosz G, Heling KS, et al. Maxillary gap at 11-13 weeks' gestation: marker of cleft lip and palate. Ultrasound Obstet Gynecol. 2015;46(6):665-9.
Chaoui, R., Orosz, G., Heling, K. S., Sarut-Lopez, A., & Nicolaides, K. H. (2015). Maxillary gap at 11-13 weeks' gestation: marker of cleft lip and palate. Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 46(6), 665-9. https://doi.org/10.1002/uog.15675
Chaoui R, et al. Maxillary Gap at 11-13 Weeks' Gestation: Marker of Cleft Lip and Palate. Ultrasound Obstet Gynecol. 2015;46(6):665-9. PubMed PMID: 26277990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maxillary gap at 11-13 weeks' gestation: marker of cleft lip and palate. AU - Chaoui,R, AU - Orosz,G, AU - Heling,K S, AU - Sarut-Lopez,A, AU - Nicolaides,K H, Y1 - 2015/11/08/ PY - 2015/07/06/received PY - 2015/08/10/revised PY - 2015/08/11/accepted PY - 2015/8/18/entrez PY - 2015/8/19/pubmed PY - 2016/9/13/medline KW - cleft lip KW - cleft palate KW - maxillary gap SP - 665 EP - 9 JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JO - Ultrasound Obstet Gynecol VL - 46 IS - 6 N2 - OBJECTIVE: To describe a new sign of cleft lip and palate (CLP), the maxillary gap, which is visible in the mid-sagittal plane of the fetal face used routinely for measurement of nuchal translucency thickness. METHODS: This was a retrospective study of stored images of the mid-sagittal view of the fetal face at 11-13 weeks' gestation in 86 cases of CLP and 86 normal controls. The images were examined to determine if a maxillary gap was present, in which case its size was measured. RESULTS: In 37 (43.0%) cases of CLP the defect was isolated and in 49 (57.0%) there were additional fetal defects. In the isolated CLP group, the diagnosis of facial cleft was made in the first trimester in nine (24.3%) cases and in the second trimester in 28 (75.7%). In the group with additional defects, the diagnosis of facial cleft was made in the first trimester in 46 (93.9%) cases and in the second trimester in three (6.1%). A maxillary gap was observed in 96% of cases of CLP with additional defects, in 65% of those with isolated CLP and in 7% of normal fetuses. There was a large gap (>1.5 mm) or complete absence of signals from the maxilla in the midline in 69% of cases of CLP with additional defects, in 35% of those with isolated CLP and in none of the normal controls. CONCLUSIONS: The maxillary gap is a new simple marker of possible CLP, which could increase the detection rate of CLP, especially in isolated cases. SN - 1469-0705 UR - https://www.unboundmedicine.com/medline/citation/26277990/Maxillary_gap_at_11_13_weeks'_gestation:_marker_of_cleft_lip_and_palate_ L2 - https://doi.org/10.1002/uog.15675 DB - PRIME DP - Unbound Medicine ER -