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Could MicroRNAs be Regulators of Gout Pathogenesis?
Cell Physiol Biochem. 2015; 36(6):2085-92.CP

Abstract

MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang Y
Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xu D
No affiliation info available
Wang B
No affiliation info available
Hou X
No affiliation info available

MeSH

ChemokinesGoutHumansHyperuricemiaInflammasomesMicroRNAsToll-Like Receptors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26279417

Citation

Wang, Yangang, et al. "Could MicroRNAs Be Regulators of Gout Pathogenesis?" Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, vol. 36, no. 6, 2015, pp. 2085-92.
Wang Y, Xu D, Wang B, et al. Could MicroRNAs be Regulators of Gout Pathogenesis? Cell Physiol Biochem. 2015;36(6):2085-92.
Wang, Y., Xu, D., Wang, B., & Hou, X. (2015). Could MicroRNAs be Regulators of Gout Pathogenesis? Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 36(6), 2085-92. https://doi.org/10.1159/000430176
Wang Y, et al. Could MicroRNAs Be Regulators of Gout Pathogenesis. Cell Physiol Biochem. 2015;36(6):2085-92. PubMed PMID: 26279417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could MicroRNAs be Regulators of Gout Pathogenesis? AU - Wang,Yangang, AU - Xu,Donghua, AU - Wang,Bin, AU - Hou,Xu, Y1 - 2015/07/21/ PY - 2015/04/08/accepted PY - 2015/8/18/entrez PY - 2015/8/19/pubmed PY - 2016/5/25/medline SP - 2085 EP - 92 JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology JO - Cell Physiol Biochem VL - 36 IS - 6 N2 - MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout. SN - 1421-9778 UR - https://www.unboundmedicine.com/medline/citation/26279417/Could_MicroRNAs_be_Regulators_of_Gout_Pathogenesis DB - PRIME DP - Unbound Medicine ER -