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Determination of Corynebacterium pseudotuberculosis prevalence and antimicrobial susceptibility pattern of isolates from lymph nodes of sheep and goats at an organic export abattoir, Modjo, Ethiopia.
Lett Appl Microbiol. 2015 Nov; 61(5):469-76.LA

Abstract

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a suppurative abscessation in the superficial and internal lymph nodes and internal organs of small ruminants. This study was conducted on the superficial lymph nodes and carcasses of 768 small ruminants slaughtered at a slaughterhouse during the study period; 82 had abscesses or caseous lymphadenitis. The most frequent sites of abscesses in goats were the prescapular (34, 5·54%) and prefemoral lymph nodes (24, 3·91%) respectively. Similar patterns were observed in sheep. The prevalence of caseous lymphadenitis was found to be significantly higher in adult than in young animals, in both species (P < 0·05). The age-wise prevalence rates of lesions on post-mortem inspection, at 95% CI, were 2·7% (2·3-3·1%) and 3·1% (2·8-3·4%) in young sheep and goats, respectively, and 24·4% (17·4-31·4%) and 27·5% (23·8-31·2%) in adult sheep and goats respectively. Corynebacterium pseudotuberculosis isolates were recovered from 72% (59/82) of animals found to have post-mortem evidence of abscesses. The Coryne. pseudotuberculosis isolates were susceptible to the antibiotics norfloxacin, tetracycline, doxycyline HCl and kanamycine; however, resistance was observed against ampicillin, clindamycin and doxycyline HCl. In conclusion, this study reported the magnitude of the problem in the country for the first time and the authors recommend a thorough investigation of wider study areas.

SIGNIFICANCE AND IMPACT OF THE STUDY

This work presents data on the prevalence of caseous lymphadenitis in slaughtered sheep and goats as well as the isolation and antibiotic susceptibility pattern of Corynebacterium pseudotuberculosis for the first time in Ethiopia. The carcasses of small ruminants are the major livestock product exported from the country and serves as an important source of foreign currency. Assessing the impact of diseases such as caseous lymphadenitis in the industry would be of great significance. This work forms initial data that call for further wider investigations to gain complete understanding of its impact in the country.

Authors+Show Affiliations

College of Veterinary Medicine, Haramaya University, Dire Dawa, Ethiopia.Institute of Biotechnology, College of Natural & Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26280351

Citation

Abebe, D, and T Sisay Tessema. "Determination of Corynebacterium Pseudotuberculosis Prevalence and Antimicrobial Susceptibility Pattern of Isolates From Lymph Nodes of Sheep and Goats at an Organic Export Abattoir, Modjo, Ethiopia." Letters in Applied Microbiology, vol. 61, no. 5, 2015, pp. 469-76.
Abebe D, Sisay Tessema T. Determination of Corynebacterium pseudotuberculosis prevalence and antimicrobial susceptibility pattern of isolates from lymph nodes of sheep and goats at an organic export abattoir, Modjo, Ethiopia. Lett Appl Microbiol. 2015;61(5):469-76.
Abebe, D., & Sisay Tessema, T. (2015). Determination of Corynebacterium pseudotuberculosis prevalence and antimicrobial susceptibility pattern of isolates from lymph nodes of sheep and goats at an organic export abattoir, Modjo, Ethiopia. Letters in Applied Microbiology, 61(5), 469-76. https://doi.org/10.1111/lam.12482
Abebe D, Sisay Tessema T. Determination of Corynebacterium Pseudotuberculosis Prevalence and Antimicrobial Susceptibility Pattern of Isolates From Lymph Nodes of Sheep and Goats at an Organic Export Abattoir, Modjo, Ethiopia. Lett Appl Microbiol. 2015;61(5):469-76. PubMed PMID: 26280351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of Corynebacterium pseudotuberculosis prevalence and antimicrobial susceptibility pattern of isolates from lymph nodes of sheep and goats at an organic export abattoir, Modjo, Ethiopia. AU - Abebe,D, AU - Sisay Tessema,T, Y1 - 2015/09/29/ PY - 2015/01/28/received PY - 2015/08/05/revised PY - 2015/08/05/accepted PY - 2015/8/18/entrez PY - 2015/8/19/pubmed PY - 2016/5/18/medline KW - Corynebacterium pseudotuberculosis KW - antimicrobial agents KW - caseous lymphadenitis KW - goat KW - lymph nodes KW - sheep SP - 469 EP - 76 JF - Letters in applied microbiology JO - Lett. Appl. Microbiol. VL - 61 IS - 5 N2 - UNLABELLED: Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a suppurative abscessation in the superficial and internal lymph nodes and internal organs of small ruminants. This study was conducted on the superficial lymph nodes and carcasses of 768 small ruminants slaughtered at a slaughterhouse during the study period; 82 had abscesses or caseous lymphadenitis. The most frequent sites of abscesses in goats were the prescapular (34, 5·54%) and prefemoral lymph nodes (24, 3·91%) respectively. Similar patterns were observed in sheep. The prevalence of caseous lymphadenitis was found to be significantly higher in adult than in young animals, in both species (P < 0·05). The age-wise prevalence rates of lesions on post-mortem inspection, at 95% CI, were 2·7% (2·3-3·1%) and 3·1% (2·8-3·4%) in young sheep and goats, respectively, and 24·4% (17·4-31·4%) and 27·5% (23·8-31·2%) in adult sheep and goats respectively. Corynebacterium pseudotuberculosis isolates were recovered from 72% (59/82) of animals found to have post-mortem evidence of abscesses. The Coryne. pseudotuberculosis isolates were susceptible to the antibiotics norfloxacin, tetracycline, doxycyline HCl and kanamycine; however, resistance was observed against ampicillin, clindamycin and doxycyline HCl. In conclusion, this study reported the magnitude of the problem in the country for the first time and the authors recommend a thorough investigation of wider study areas. SIGNIFICANCE AND IMPACT OF THE STUDY: This work presents data on the prevalence of caseous lymphadenitis in slaughtered sheep and goats as well as the isolation and antibiotic susceptibility pattern of Corynebacterium pseudotuberculosis for the first time in Ethiopia. The carcasses of small ruminants are the major livestock product exported from the country and serves as an important source of foreign currency. Assessing the impact of diseases such as caseous lymphadenitis in the industry would be of great significance. This work forms initial data that call for further wider investigations to gain complete understanding of its impact in the country. SN - 1472-765X UR - https://www.unboundmedicine.com/medline/citation/26280351/Determination_of_Corynebacterium_pseudotuberculosis_prevalence_and_antimicrobial_susceptibility_pattern_of_isolates_from_lymph_nodes_of_sheep_and_goats_at_an_organic_export_abattoir_Modjo_Ethiopia_ L2 - https://doi.org/10.1111/lam.12482 DB - PRIME DP - Unbound Medicine ER -