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Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16.
Food Funct 2015; 6(10):3383-92FF

Abstract

Only certain flavonoids have been shown to enhance life span. This was pointed out for e.g. myricetin in the nematode Caenorhabditis elegans. However, the structural requirements responsible for this effect are not known. We used methylated derivatives of myricetin (laricitrin, syringetin, myricetintrimethylether) to investigate if free OH moieties in the B-ring are necessary for the life span extending effect. In analogy to myricetin, all derivatives increased the life span, decreased oxidative stress (DCF) and decreased the accumulation of lipofuscin. In contrast to myricetin, the methylated compounds strongly enhanced the resistance against thermal stress. Furthermore, treatment with the derivatives induced a much stronger nuclear localization of the DAF-16 transcription factor (FoxO homologue). Additionally, no antioxidant effects and only minor effects on life span prolongation and stress resistance were detectable for the methylated compounds in a DAF-16 deficient nematode strain. Comparable to the dietary flavonoid myricetin, the methylated myricetin derivatives laricitrin, syringetin and myricetintrimethylether strongly enhance the life span of C. elegans. Therefore, OH groups of ring B are not necessary for this effect. Only the methylated compounds increase the stress resistance of the nematode which was dependent on DAF-16. These findings suggest that methylation of myricetin increases the biofunctionality.

Authors+Show Affiliations

Martin-Luther-Universität Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Biofunctionality of Secondary Plant Compounds, Weinbergweg 20, D-06120 Halle/Saale, Germany. wim.waetjen@landw.uni-halle.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26281763

Citation

Büchter, C, et al. "Methylated Derivatives of Myricetin Enhance Life Span in Caenorhabditis Elegans Dependent On the Transcription Factor DAF-16." Food & Function, vol. 6, no. 10, 2015, pp. 3383-92.
Büchter C, Ackermann D, Honnen S, et al. Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food Funct. 2015;6(10):3383-92.
Büchter, C., Ackermann, D., Honnen, S., Arnold, N., Havermann, S., Koch, K., & Wätjen, W. (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food & Function, 6(10), pp. 3383-92. doi:10.1039/c5fo00463b.
Büchter C, et al. Methylated Derivatives of Myricetin Enhance Life Span in Caenorhabditis Elegans Dependent On the Transcription Factor DAF-16. Food Funct. 2015;6(10):3383-92. PubMed PMID: 26281763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. AU - Büchter,C, AU - Ackermann,D, AU - Honnen,S, AU - Arnold,N, AU - Havermann,S, AU - Koch,K, AU - Wätjen,W, PY - 2015/8/19/entrez PY - 2015/8/19/pubmed PY - 2016/8/11/medline SP - 3383 EP - 92 JF - Food & function JO - Food Funct VL - 6 IS - 10 N2 - Only certain flavonoids have been shown to enhance life span. This was pointed out for e.g. myricetin in the nematode Caenorhabditis elegans. However, the structural requirements responsible for this effect are not known. We used methylated derivatives of myricetin (laricitrin, syringetin, myricetintrimethylether) to investigate if free OH moieties in the B-ring are necessary for the life span extending effect. In analogy to myricetin, all derivatives increased the life span, decreased oxidative stress (DCF) and decreased the accumulation of lipofuscin. In contrast to myricetin, the methylated compounds strongly enhanced the resistance against thermal stress. Furthermore, treatment with the derivatives induced a much stronger nuclear localization of the DAF-16 transcription factor (FoxO homologue). Additionally, no antioxidant effects and only minor effects on life span prolongation and stress resistance were detectable for the methylated compounds in a DAF-16 deficient nematode strain. Comparable to the dietary flavonoid myricetin, the methylated myricetin derivatives laricitrin, syringetin and myricetintrimethylether strongly enhance the life span of C. elegans. Therefore, OH groups of ring B are not necessary for this effect. Only the methylated compounds increase the stress resistance of the nematode which was dependent on DAF-16. These findings suggest that methylation of myricetin increases the biofunctionality. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/26281763/Methylated_derivatives_of_myricetin_enhance_life_span_in_Caenorhabditis_elegans_dependent_on_the_transcription_factor_DAF_16_ L2 - https://doi.org/10.1039/c5fo00463b DB - PRIME DP - Unbound Medicine ER -