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In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata.
J Mycol Med. 2015 Sep; 25(3):213-7.JM

Abstract

In the present study, the antifungal activity of essential oils obtained from Origanum vulgare (oregano), Cinnamomum zeylanicum (cinnamon), Lippia graveolens (Mexican oregano), Thymus vulgaris (thyme), Salvia officinalis (sage), Rosmarinus officinalis (rosemary), Ocimum basilicum (basil) and Zingiber officinale (ginger) were assessed against Candida glabrata isolates. One group contained 30 fluconazole-susceptible C. glabrata isolates, and the second group contained fluconazole-resistant isolates derived from the first group after the in vitro induction of fluconazole-resistance, for a total of 60 tested isolates. The broth microdilution methodology was used. Concentrations of 50μg/mL, 100μg/mL, 200μg/mL, 400μg/mL, 800μg/mL, 1600μg/mL and 3200μg/mL of the essential oils were used, and the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined. Thyme, sage, rosemary, basil and ginger essential oils showed no antifungal activity at the tested concentrations. Antimicrobial activity less than or equal to 3200μg/mL was observed for oregano, Mexican oregano and cinnamon essential oils. Both the oregano and Mexican oregano essential oils showed high levels of antifungal activity against the fluconazole-susceptible C. glabrata group, whereas the cinnamon essential oil showed the best antifungal activity against the fluconazole-resistant C. glabrata isolates.

Authors+Show Affiliations

Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: isaurahs@hotmail.com.Pharmacology Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: erico.loreto@gmail.com.Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: luana.farma@hotmail.com.Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil; Meridional Faculty, Passo Fundo, RS, Brazil. Electronic address: debora_alves6@hotmail.com.Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: tarcieliventurini@gmail.com.Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil.Pharmacology Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: janio.santurio@gmail.com.Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: sydneyalves.ufsm@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26281965

Citation

Soares, I H., et al. "In Vitro Activity of Essential Oils Extracted From Condiments Against Fluconazole-resistant and -sensitive Candida Glabrata." Journal De Mycologie Medicale, vol. 25, no. 3, 2015, pp. 213-7.
Soares IH, Loreto ÉS, Rossato L, et al. In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata. J Mycol Med. 2015;25(3):213-7.
Soares, I. H., Loreto, É. S., Rossato, L., Mario, D. N., Venturini, T. P., Baldissera, F., Santurio, J. M., & Alves, S. H. (2015). In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata. Journal De Mycologie Medicale, 25(3), 213-7. https://doi.org/10.1016/j.mycmed.2015.06.003
Soares IH, et al. In Vitro Activity of Essential Oils Extracted From Condiments Against Fluconazole-resistant and -sensitive Candida Glabrata. J Mycol Med. 2015;25(3):213-7. PubMed PMID: 26281965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata. AU - Soares,I H, AU - Loreto,É S, AU - Rossato,L, AU - Mario,D N, AU - Venturini,T P, AU - Baldissera,F, AU - Santurio,J M, AU - Alves,S H, Y1 - 2015/08/14/ PY - 2014/07/28/received PY - 2015/06/22/revised PY - 2015/06/25/accepted PY - 2015/8/19/entrez PY - 2015/8/19/pubmed PY - 2016/4/14/medline KW - Activité antifongique KW - Antifungal activity KW - Candida glabrata KW - Essential oil KW - Huile essentielle SP - 213 EP - 7 JF - Journal de mycologie medicale JO - J Mycol Med VL - 25 IS - 3 N2 - In the present study, the antifungal activity of essential oils obtained from Origanum vulgare (oregano), Cinnamomum zeylanicum (cinnamon), Lippia graveolens (Mexican oregano), Thymus vulgaris (thyme), Salvia officinalis (sage), Rosmarinus officinalis (rosemary), Ocimum basilicum (basil) and Zingiber officinale (ginger) were assessed against Candida glabrata isolates. One group contained 30 fluconazole-susceptible C. glabrata isolates, and the second group contained fluconazole-resistant isolates derived from the first group after the in vitro induction of fluconazole-resistance, for a total of 60 tested isolates. The broth microdilution methodology was used. Concentrations of 50μg/mL, 100μg/mL, 200μg/mL, 400μg/mL, 800μg/mL, 1600μg/mL and 3200μg/mL of the essential oils were used, and the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined. Thyme, sage, rosemary, basil and ginger essential oils showed no antifungal activity at the tested concentrations. Antimicrobial activity less than or equal to 3200μg/mL was observed for oregano, Mexican oregano and cinnamon essential oils. Both the oregano and Mexican oregano essential oils showed high levels of antifungal activity against the fluconazole-susceptible C. glabrata group, whereas the cinnamon essential oil showed the best antifungal activity against the fluconazole-resistant C. glabrata isolates. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/26281965/In_vitro_activity_of_essential_oils_extracted_from_condiments_against_fluconazole_resistant_and__sensitive_Candida_glabrata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1156-5233(15)00110-9 DB - PRIME DP - Unbound Medicine ER -