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[Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty].
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug; 17(8):763-8.ZD

Abstract

OBJECTIVE

To explore the effects of obesity on the peak level of luteinizing hormone (LH) in the gonadotropin-releasing hormone (GnRH) agonist test and obesity-related hormones in girls with central precocious puberty (CPP).

METHODS

Three hundred and thirty-three girls with CPP who underwent the GnRH agonist test between 2012 and 2014 were classified into three groups: normal weight (n=123), overweight (n=108), and obesity (n=102), according to body mass index (BMI). The sexual development indices were compared between the three groups. Twenty girls were randomly selected from each group for evaluation of the serum levels of leptin, sex hormone binding globulin (SHBG), neurokinin B, and kisspeptin. The correlation of BMI with the levels of various hormones was assessed using Pearson correlation analysis.

RESULTS

There was no significant difference in mean age at diagnosis between the three groups; however, the bone age was significantly higher in the overweight and obesity groups than in the normal weight group (P<0.05). The peak level of LH in the GnRH agonist test and SHBG level in the normal weight group were significantly higher than those in the overweight and the obesity groups, while the serum levels of leptin and neurokinin B were significantly lower in the normal weight group than in the overweight and the obesity groups (P<0.05). BMI was negatively correlated with the peak level of LH in the GnRH agonist test and SHBG level (P<0.05), and positively correlated with the levels of leptin and neurokinin B (P<0.05).

CONCLUSIONS

The effects of BMI on the result of the GnRH agonist test and levels of obesity-related hormones should be taken into account in girls with precocious puberty.

Authors+Show Affiliations

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China. fif68@qq.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

26287335

Citation

Zhou, Xue-Lian, et al. "[Effects of Obesity On Peak Level of Luteinizing Hormone in Gonadotropin-releasing Hormone Agonist Test and Obesity-related Hormones in Girls With Central Precocious Puberty]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 17, no. 8, 2015, pp. 763-8.
Zhou XL, Fu JF, Jin JH, et al. [Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17(8):763-8.
Zhou, X. L., Fu, J. F., Jin, J. H., Dong, G. P., Jiang, Y. J., Huang, K., Chen, X. F., & Wu, W. (2015). [Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 17(8), 763-8.
Zhou XL, et al. [Effects of Obesity On Peak Level of Luteinizing Hormone in Gonadotropin-releasing Hormone Agonist Test and Obesity-related Hormones in Girls With Central Precocious Puberty]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17(8):763-8. PubMed PMID: 26287335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty]. AU - Zhou,Xue-Lian, AU - Fu,Jun-Fen, AU - Jin,Ju-Hua, AU - Dong,Guan-Ping, AU - Jiang,You-Jun, AU - Huang,Ke, AU - Chen,Xue-Feng, AU - Wu,Wei, PY - 2015/8/20/entrez PY - 2015/8/20/pubmed PY - 2016/1/8/medline SP - 763 EP - 8 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 17 IS - 8 N2 - OBJECTIVE: To explore the effects of obesity on the peak level of luteinizing hormone (LH) in the gonadotropin-releasing hormone (GnRH) agonist test and obesity-related hormones in girls with central precocious puberty (CPP). METHODS: Three hundred and thirty-three girls with CPP who underwent the GnRH agonist test between 2012 and 2014 were classified into three groups: normal weight (n=123), overweight (n=108), and obesity (n=102), according to body mass index (BMI). The sexual development indices were compared between the three groups. Twenty girls were randomly selected from each group for evaluation of the serum levels of leptin, sex hormone binding globulin (SHBG), neurokinin B, and kisspeptin. The correlation of BMI with the levels of various hormones was assessed using Pearson correlation analysis. RESULTS: There was no significant difference in mean age at diagnosis between the three groups; however, the bone age was significantly higher in the overweight and obesity groups than in the normal weight group (P<0.05). The peak level of LH in the GnRH agonist test and SHBG level in the normal weight group were significantly higher than those in the overweight and the obesity groups, while the serum levels of leptin and neurokinin B were significantly lower in the normal weight group than in the overweight and the obesity groups (P<0.05). BMI was negatively correlated with the peak level of LH in the GnRH agonist test and SHBG level (P<0.05), and positively correlated with the levels of leptin and neurokinin B (P<0.05). CONCLUSIONS: The effects of BMI on the result of the GnRH agonist test and levels of obesity-related hormones should be taken into account in girls with precocious puberty. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/26287335/[Effects_of_obesity_on_peak_level_of_luteinizing_hormone_in_gonadotropin_releasing_hormone_agonist_test_and_obesity_related_hormones_in_girls_with_central_precocious_puberty]_ L2 - http://www.zgddek.com/EN/abstract/abstract13708.shtml DB - PRIME DP - Unbound Medicine ER -