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Subtype distribution of hepatitis C virus in Jiangsu, China.
J Med Virol. 2016 Mar; 88(3):498-505.JM

Abstract

Hepatitis C virus (HCV) genotype distribution varied by regions and transmission modes. In this study, we investigated HCV genotype distribution in five cities of Jiangsu, China, all of which are located in the Yangtze River Delta Region. A total of 363 samples were collected during 2011-2012. C/E2 and NS5B fragments of HCV were amplified using a multiple RT-nested PCR strategy and subjected to sequencing. Phylogenetic analysis was performed for HCV genotyping. Among 106 PCR positive cases, HCV subtypes 1a (0.9%), 1b (61.3%), 2a (15.1%), 3a (4.7%), 3b (9.4%), 6a (6.6%), and 6n (1.9%) were detected. Together with our previous data, we found that HCV subtypes were more among injection drug users (IDUs) (nine) than among general population (GP) (six), and the most common subtype among GP was 1b (73.9%), followed by 2a (14.5%), while the top four common subtypes among IDUs were 3a, 1b, 3b, and 6a, with similar prevalence rates (24.4%, 22.7%, 20.9%, and 17.4%, respectively). There were nine HCV subtypes prevalent among IDUs in Jiangsu, more than those in Xinjiang, Hubei, Yunnan, Guangxi, Guangdong, and Hong Kong. The top four common subtypes among IDUs in Jiangsu covered all the two most common HCV subtypes (except 6n subtype) observed in six targeted provinces/region. These results suggested that Jiangsu may be an important gathering place for various HCV subtypes and the gathering may be involved in the large scale of population migration from other regions of China to Eastern China.

Authors+Show Affiliations

Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China.Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China.Medical Laboratory of Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.Jiangsu Center for Disease Control and Prevention, Nanjing, Jiangsu, China.The Third People's Hospital of Nantong, Nantong, Jiangsu, China.Zhenjiang Center of Disease Control and Prevention, Zhenjiang, Jiangsu, China.Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China.Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China. Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26288243

Citation

Qi, Yinle, et al. "Subtype Distribution of Hepatitis C Virus in Jiangsu, China." Journal of Medical Virology, vol. 88, no. 3, 2016, pp. 498-505.
Qi Y, Chen Q, Hao F, et al. Subtype distribution of hepatitis C virus in Jiangsu, China. J Med Virol. 2016;88(3):498-505.
Qi, Y., Chen, Q., Hao, F., Wan, Z., Guo, H., Lu, R., Mao, L., Du, H., Lu, J., & Zhang, C. (2016). Subtype distribution of hepatitis C virus in Jiangsu, China. Journal of Medical Virology, 88(3), 498-505. https://doi.org/10.1002/jmv.24356
Qi Y, et al. Subtype Distribution of Hepatitis C Virus in Jiangsu, China. J Med Virol. 2016;88(3):498-505. PubMed PMID: 26288243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subtype distribution of hepatitis C virus in Jiangsu, China. AU - Qi,Yinle, AU - Chen,Qianqian, AU - Hao,Fangyuan, AU - Wan,Zhenzhou, AU - Guo,Hongxiong, AU - Lu,Renfei, AU - Mao,Lingxiang, AU - Du,Hong, AU - Lu,Jian, AU - Zhang,Chiyu, Y1 - 2015/08/31/ PY - 2015/08/13/accepted PY - 2015/8/20/entrez PY - 2015/8/20/pubmed PY - 2016/11/1/medline KW - HCV KW - Jiangsu KW - general population KW - injection drug users KW - population migration KW - subtype SP - 498 EP - 505 JF - Journal of medical virology JO - J Med Virol VL - 88 IS - 3 N2 - Hepatitis C virus (HCV) genotype distribution varied by regions and transmission modes. In this study, we investigated HCV genotype distribution in five cities of Jiangsu, China, all of which are located in the Yangtze River Delta Region. A total of 363 samples were collected during 2011-2012. C/E2 and NS5B fragments of HCV were amplified using a multiple RT-nested PCR strategy and subjected to sequencing. Phylogenetic analysis was performed for HCV genotyping. Among 106 PCR positive cases, HCV subtypes 1a (0.9%), 1b (61.3%), 2a (15.1%), 3a (4.7%), 3b (9.4%), 6a (6.6%), and 6n (1.9%) were detected. Together with our previous data, we found that HCV subtypes were more among injection drug users (IDUs) (nine) than among general population (GP) (six), and the most common subtype among GP was 1b (73.9%), followed by 2a (14.5%), while the top four common subtypes among IDUs were 3a, 1b, 3b, and 6a, with similar prevalence rates (24.4%, 22.7%, 20.9%, and 17.4%, respectively). There were nine HCV subtypes prevalent among IDUs in Jiangsu, more than those in Xinjiang, Hubei, Yunnan, Guangxi, Guangdong, and Hong Kong. The top four common subtypes among IDUs in Jiangsu covered all the two most common HCV subtypes (except 6n subtype) observed in six targeted provinces/region. These results suggested that Jiangsu may be an important gathering place for various HCV subtypes and the gathering may be involved in the large scale of population migration from other regions of China to Eastern China. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/26288243/Subtype_distribution_of_hepatitis_C_virus_in_Jiangsu_China_ L2 - https://doi.org/10.1002/jmv.24356 DB - PRIME DP - Unbound Medicine ER -