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Antimicrobial activities of Saudi honey against Pseudomonas aeruginosa.


Five types of imported and local honey were screened for both their bacteriocidal/bacteriostatic activities against both Imipenem resistant and sensitive Pseudomonas aeruginosa in both Brain Heart infusion broth and Mueller-Hinton agar. The results indicated that the effect was concentration and type of honey dependant. All types of honey tested exerted a full inhibition of bacterial growth at the highest concentration tested of 50% at 24 h of contact. The inhibitory effect of honey on bacterial growth was clear with concentrations of 20% and 10% and this effect was most evident in the case of Manuka honey as compared to Nigella sativa honey and Seder honey. Manuka honey UMF +20 showed a bacteriocidal activity on both Imipenem resistant and sensitive P. aeruginosa, while Seder honey and N. sativa honey exerted only a bacteriostatic effect. Manuka honey UMF +10 showed most effect on antimicrobial resistance. Manuka honey UMF +10 had an effect on modulation of Imipenem resistant P. aeruginosa.


The results indicated that various types of honey affected the test organisms differently. Modulation of antimicrobial resistance was seen in the case Manuka honey UMF +10.


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    Biology Department, Faculty of Science, King Abdulaziz University (KAU), Saudi Arabia.


    Biology Department, Faculty of Science, King Abdulaziz University (KAU), Saudi Arabia.


    Department of Microbiology and Immunology, Faculty of Medicine, Egypt.


    Department of Animal and Veterinary Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon ; Biochemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia.


    Department of Hematology and Yousef Abdullatif Jameel Chair of Prophetic Medicine Application, Faculty of Medicine, KAU, Saudi Arabia.

    Special Infectious Agents Unit, King Fahd Medical Research Center, KAU, Saudi Arabia.


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    Journal Article



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