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Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients.
PLoS One 2015; 10(8):e0136071Plos

Abstract

BACKGROUND

Early identification of patients at risk for delirium is important, since adequate well timed interventions could prevent occurrence of delirium and related detrimental outcomes. The aim of this study is to evaluate prognostic factors for delirium, including factors describing frailty, in elderly patients undergoing major surgery.

METHODS

We included patients of 65 years and older, who underwent elective surgery from March 2013 to November 2014. Patients had surgery for Abdominal Aortic Aneurysm (AAA) or colorectal cancer. Delirium was scored prospectively using the Delirium Observation Screening Scale. Pre- and peri-operative predictors of delirium were analyzed using regression analysis. Outcomes after delirium included adverse events, length of hospital stay, discharge destination and mortality.

RESULTS

We included 232 patients. 51 (22%) underwent surgery for AAA and 181 (78%) for colorectal cancer. Postoperative delirium occurred in 35 patients (15%). Predictors of postoperative delirium included: delirium in medical history (Odds Ratio 12 [95% Confidence Interval 2.7-50]), advancing age (Odds Ratio 2.0 [95% Confidence Interval 1.1-3.8]) per 10 years, and ASA-score ≥3 (Odds Ratio 2.6 [95% Confidence Interval 1.1-5.9]). Occurrence of delirium was related to an increase in adverse events, length of hospital stay and mortality.

CONCLUSION

Postoperative delirium is a frequent complication after major surgery in elderly patients and is related to an increase in adverse events, length of hospital stay, and mortality. A delirium in the medical history, advanced age, and ASA-score may assist in defining patients at increased risk for delirium. Further attention to prevention of delirium is essential in elderly patients undergoing major surgery.

Authors+Show Affiliations

Department of Surgery, Amphia Hospital, Breda, The Netherlands.Department of Surgery, Amphia Hospital, Breda, The Netherlands.Department of Surgery, Amphia Hospital, Breda, The Netherlands.Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.Department of Surgery, Amphia Hospital, Breda, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26291459

Citation

Raats, Jelle W., et al. "Risk Factors and Outcomes for Postoperative Delirium After Major Surgery in Elderly Patients." PloS One, vol. 10, no. 8, 2015, pp. e0136071.
Raats JW, van Eijsden WA, Crolla RM, et al. Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients. PLoS ONE. 2015;10(8):e0136071.
Raats, J. W., van Eijsden, W. A., Crolla, R. M., Steyerberg, E. W., & van der Laan, L. (2015). Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients. PloS One, 10(8), pp. e0136071. doi:10.1371/journal.pone.0136071.
Raats JW, et al. Risk Factors and Outcomes for Postoperative Delirium After Major Surgery in Elderly Patients. PLoS ONE. 2015;10(8):e0136071. PubMed PMID: 26291459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients. AU - Raats,Jelle W, AU - van Eijsden,Wilbert A, AU - Crolla,Rogier M P H, AU - Steyerberg,Ewout W, AU - van der Laan,Lijckle, Y1 - 2015/08/20/ PY - 2015/03/19/received PY - 2015/07/29/accepted PY - 2015/8/21/entrez PY - 2015/8/21/pubmed PY - 2016/5/25/medline SP - e0136071 EP - e0136071 JF - PloS one JO - PLoS ONE VL - 10 IS - 8 N2 - BACKGROUND: Early identification of patients at risk for delirium is important, since adequate well timed interventions could prevent occurrence of delirium and related detrimental outcomes. The aim of this study is to evaluate prognostic factors for delirium, including factors describing frailty, in elderly patients undergoing major surgery. METHODS: We included patients of 65 years and older, who underwent elective surgery from March 2013 to November 2014. Patients had surgery for Abdominal Aortic Aneurysm (AAA) or colorectal cancer. Delirium was scored prospectively using the Delirium Observation Screening Scale. Pre- and peri-operative predictors of delirium were analyzed using regression analysis. Outcomes after delirium included adverse events, length of hospital stay, discharge destination and mortality. RESULTS: We included 232 patients. 51 (22%) underwent surgery for AAA and 181 (78%) for colorectal cancer. Postoperative delirium occurred in 35 patients (15%). Predictors of postoperative delirium included: delirium in medical history (Odds Ratio 12 [95% Confidence Interval 2.7-50]), advancing age (Odds Ratio 2.0 [95% Confidence Interval 1.1-3.8]) per 10 years, and ASA-score ≥3 (Odds Ratio 2.6 [95% Confidence Interval 1.1-5.9]). Occurrence of delirium was related to an increase in adverse events, length of hospital stay and mortality. CONCLUSION: Postoperative delirium is a frequent complication after major surgery in elderly patients and is related to an increase in adverse events, length of hospital stay, and mortality. A delirium in the medical history, advanced age, and ASA-score may assist in defining patients at increased risk for delirium. Further attention to prevention of delirium is essential in elderly patients undergoing major surgery. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26291459/Risk_Factors_and_Outcomes_for_Postoperative_Delirium_after_Major_Surgery_in_Elderly_Patients_ L2 - http://dx.plos.org/10.1371/journal.pone.0136071 DB - PRIME DP - Unbound Medicine ER -