Tags

Type your tag names separated by a space and hit enter

Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea.
Gynecol Endocrinol. 2015 Oct; 31(10):774-8.GE

Abstract

OBJECTIVE

To study the three cycles effect on primary dysmenorrhea of the monophasic 24/4 estradiol/nomegestrol acetate (E2/NOMAC) and of the 21/7 ethinyl-estradiol/chlormadinone acetate (EE/CMA) oral contraceptive. The tolerability and the effect of both preparations on metabolism and health-related quality of life were also evaluated.

DESIGN

Prospective observational cohort study.

SETTING

Tertiary gynecologic center for pelvic pain.

PATIENTS

Subjects with primary dysmenorrhea requiring an oral contraceptive, who spontaneously selected either E2/NOMAC (n = 20) or EE/CMA (n = 20).

MAIN OUTCOME MEASURES

Visual Analogue Scale (VAS) score for dysmenorrhea, Short Form-36 questionnaire for health-related quality of life, lipoproteins and days of menstrual bleeding (withdrawal bleeding during oral contraceptive).

RESULTS

Mean age and body mass index (BMI) were similar between the two groups. The final analysis was performed on 34 women, 15 in E2/NOMAC and 19 in EE/CMA group. Compliance with treatment was significantly higher with EE/CMA (100%) than E2/NOMAC (75%) (p = 0.02). Both treatments significantly (p < 0.0001) reduced VAS of primary dysmenorrhea, similarly (E2/NOMAC by a mean of 74.7%, EE/CMA by a mean of 78.4%; p = 0.973). Only E2/NOMAC significantly increased SF-36 score (p = 0.001), both in physical (p = 0.001) and mental domains (p = 0.004). The mean number of days of menstrual bleeding was significantly reduced in E2/NOMAC group (from 4.86 ± 1.20 d to 2.64 ± 1.59 d, p = 0.0005 versus baseline, p = 0.007 versus EE/CMA group). BMI did not vary in either group. E2/NOMAC did not change lipoproteins and apoproteins while EE/CMA increased total cholesterol (p = 0.0114), HDL-cholesterol (p = 0.0008), triglycerides (p = 0.002), apoprotein-A1 (Apo-A1; p = 0.0006) and apopoprotein-B (Apo-B; p = 0.008), decreasing LDL/HDL ratio (p = 0.024).

CONCLUSIONS

Both oral contraceptives reduced similarly primary dysmenorrhea, with E2/NOMAC also reducing withdrawal bleedings and being neutral on lipid metabolism.

Authors+Show Affiliations

a Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit , Azienda Ospedaliero Universitaria Policlinico of Modena , Modena , Italy and.a Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit , Azienda Ospedaliero Universitaria Policlinico of Modena , Modena , Italy and.a Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit , Azienda Ospedaliero Universitaria Policlinico of Modena , Modena , Italy and.a Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit , Azienda Ospedaliero Universitaria Policlinico of Modena , Modena , Italy and.b Department of Neurosciences and Reproductive Sciences , University of Naples Federico II , Naples , Italy.a Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology Unit , Azienda Ospedaliero Universitaria Policlinico of Modena , Modena , Italy and.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

26291811

Citation

Grandi, Giovanni, et al. "Effect of Oral Contraceptives Containing Estradiol and Nomegestrol Acetate or Ethinyl-estradiol and Chlormadinone Acetate On Primary Dysmenorrhea." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 31, no. 10, 2015, pp. 774-8.
Grandi G, Napolitano A, Xholli A, et al. Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. Gynecol Endocrinol. 2015;31(10):774-8.
Grandi, G., Napolitano, A., Xholli, A., Tirelli, A., Di Carlo, C., & Cagnacci, A. (2015). Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 31(10), 774-8. https://doi.org/10.3109/09513590.2015.1063118
Grandi G, et al. Effect of Oral Contraceptives Containing Estradiol and Nomegestrol Acetate or Ethinyl-estradiol and Chlormadinone Acetate On Primary Dysmenorrhea. Gynecol Endocrinol. 2015;31(10):774-8. PubMed PMID: 26291811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. AU - Grandi,Giovanni, AU - Napolitano,Antonella, AU - Xholli,Anjeza, AU - Tirelli,Alessandra, AU - Di Carlo,Costantino, AU - Cagnacci,Angelo, Y1 - 2015/08/17/ PY - 2015/8/21/entrez PY - 2015/8/21/pubmed PY - 2016/9/10/medline KW - Chlormadinone acetate KW - dysmenorrhea KW - estradiol KW - ethinyl-estradiol KW - metabolism KW - nomegestrol acetate KW - primary dysmenorrhea KW - quality of life SP - 774 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 31 IS - 10 N2 - OBJECTIVE: To study the three cycles effect on primary dysmenorrhea of the monophasic 24/4 estradiol/nomegestrol acetate (E2/NOMAC) and of the 21/7 ethinyl-estradiol/chlormadinone acetate (EE/CMA) oral contraceptive. The tolerability and the effect of both preparations on metabolism and health-related quality of life were also evaluated. DESIGN: Prospective observational cohort study. SETTING: Tertiary gynecologic center for pelvic pain. PATIENTS: Subjects with primary dysmenorrhea requiring an oral contraceptive, who spontaneously selected either E2/NOMAC (n = 20) or EE/CMA (n = 20). MAIN OUTCOME MEASURES: Visual Analogue Scale (VAS) score for dysmenorrhea, Short Form-36 questionnaire for health-related quality of life, lipoproteins and days of menstrual bleeding (withdrawal bleeding during oral contraceptive). RESULTS: Mean age and body mass index (BMI) were similar between the two groups. The final analysis was performed on 34 women, 15 in E2/NOMAC and 19 in EE/CMA group. Compliance with treatment was significantly higher with EE/CMA (100%) than E2/NOMAC (75%) (p = 0.02). Both treatments significantly (p < 0.0001) reduced VAS of primary dysmenorrhea, similarly (E2/NOMAC by a mean of 74.7%, EE/CMA by a mean of 78.4%; p = 0.973). Only E2/NOMAC significantly increased SF-36 score (p = 0.001), both in physical (p = 0.001) and mental domains (p = 0.004). The mean number of days of menstrual bleeding was significantly reduced in E2/NOMAC group (from 4.86 ± 1.20 d to 2.64 ± 1.59 d, p = 0.0005 versus baseline, p = 0.007 versus EE/CMA group). BMI did not vary in either group. E2/NOMAC did not change lipoproteins and apoproteins while EE/CMA increased total cholesterol (p = 0.0114), HDL-cholesterol (p = 0.0008), triglycerides (p = 0.002), apoprotein-A1 (Apo-A1; p = 0.0006) and apopoprotein-B (Apo-B; p = 0.008), decreasing LDL/HDL ratio (p = 0.024). CONCLUSIONS: Both oral contraceptives reduced similarly primary dysmenorrhea, with E2/NOMAC also reducing withdrawal bleedings and being neutral on lipid metabolism. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/26291811/Effect_of_oral_contraceptives_containing_estradiol_and_nomegestrol_acetate_or_ethinyl_estradiol_and_chlormadinone_acetate_on_primary_dysmenorrhea_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2015.1063118 DB - PRIME DP - Unbound Medicine ER -