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Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women?

Abstract

The objective of this study is to measure serum chemerin levels in women with polycystic ovary syndrome (PCOS) and assess their relationship with clinical, metabolic, and hormonal parameters. One hundred eighteen PCOS women and 114 healthy women were recruited in this study. Their blood pressure, body mass index (BMI), waist circumference and waist-to-hip ratio (WHR), fasting insulin (FIN), fasting plasma glucose (FPG), blood serum sex hormone, and blood lipid were measured. Serum chemerin, leptin, and adiponectin were measured by ELISA. Serum chemerin was significantly higher in the obese PCOS group (47.62 ± 11.27 ng/mL) compared with non-obese PCOS (37.10 ± 9.55 ng/mL) and the obese (33.71 ± 6.17 ng/mL) and non-obese (25.78 ± 6.93 ng/mL) control groups (p < 0.05). Serum chemerin was positively related to BMI, waist circumference, WHR, testosterone (T), FPG, FIN, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), LDL-C/high-density lipoprotein(HDL-C), TC/HDL-C and serum leptin, while negatively related to glucose-to-insulin ratio (G/I), HDL-C, and adiponectin levels. Multiple linear regression analysis revealed HOMA-IR, leptin, and TC were the significant influencing factors of chemerin levels (p < 0.05). Increased serum chemerin in PCOS woman with or without obesity suggested that chemerin may be involved in the development of the pathogenesis of PCOS.

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  • Authors+Show Affiliations

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    ,

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    a Department of Obstetrics and Gynecology , West China Second University Hospital of Sichuan University , Sichuan , China.

    Source

    MeSH

    Adiponectin
    Adolescent
    Adult
    Blood Glucose
    Blood Pressure
    Body Mass Index
    Case-Control Studies
    Chemokines
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Female
    Follicle Stimulating Hormone
    Humans
    Insulin
    Insulin Resistance
    Intercellular Signaling Peptides and Proteins
    Leptin
    Linear Models
    Luteinizing Hormone
    Obesity
    Polycystic Ovary Syndrome
    Testosterone
    Triglycerides
    Waist Circumference
    Waist-Hip Ratio
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26291816

    Citation

    Yang, Shiyuan, et al. "Are Serum Chemerin Levels Different Between Obese and Non-obese Polycystic Ovary Syndrome Women?" Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 32, no. 1, 2016, pp. 38-41.
    Yang S, Wang Q, Huang W, et al. Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women? Gynecol Endocrinol. 2016;32(1):38-41.
    Yang, S., Wang, Q., Huang, W., Song, Y., Feng, G., Zhou, L., & Tan, J. (2016). Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women? Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 32(1), pp. 38-41. doi:10.3109/09513590.2015.1075501.
    Yang S, et al. Are Serum Chemerin Levels Different Between Obese and Non-obese Polycystic Ovary Syndrome Women. Gynecol Endocrinol. 2016;32(1):38-41. PubMed PMID: 26291816.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women? AU - Yang,Shiyuan, AU - Wang,Qiuyi, AU - Huang,Wei, AU - Song,Yong, AU - Feng,Guimei, AU - Zhou,Lu, AU - Tan,Jing, Y1 - 2015/08/18/ PY - 2015/8/21/entrez PY - 2015/8/21/pubmed PY - 2016/12/15/medline KW - Chemerin KW - insulin resistance KW - obese KW - polycystic ovary syndrome SP - 38 EP - 41 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 32 IS - 1 N2 - The objective of this study is to measure serum chemerin levels in women with polycystic ovary syndrome (PCOS) and assess their relationship with clinical, metabolic, and hormonal parameters. One hundred eighteen PCOS women and 114 healthy women were recruited in this study. Their blood pressure, body mass index (BMI), waist circumference and waist-to-hip ratio (WHR), fasting insulin (FIN), fasting plasma glucose (FPG), blood serum sex hormone, and blood lipid were measured. Serum chemerin, leptin, and adiponectin were measured by ELISA. Serum chemerin was significantly higher in the obese PCOS group (47.62 ± 11.27 ng/mL) compared with non-obese PCOS (37.10 ± 9.55 ng/mL) and the obese (33.71 ± 6.17 ng/mL) and non-obese (25.78 ± 6.93 ng/mL) control groups (p < 0.05). Serum chemerin was positively related to BMI, waist circumference, WHR, testosterone (T), FPG, FIN, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), LDL-C/high-density lipoprotein(HDL-C), TC/HDL-C and serum leptin, while negatively related to glucose-to-insulin ratio (G/I), HDL-C, and adiponectin levels. Multiple linear regression analysis revealed HOMA-IR, leptin, and TC were the significant influencing factors of chemerin levels (p < 0.05). Increased serum chemerin in PCOS woman with or without obesity suggested that chemerin may be involved in the development of the pathogenesis of PCOS. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/26291816/Are_serum_chemerin_levels_different_between_obese_and_non_obese_polycystic_ovary_syndrome_women L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2015.1075501 DB - PRIME DP - Unbound Medicine ER -