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Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study.
PLoS One 2015; 10(8):e0136468Plos

Abstract

BACKGROUND

Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine.

METHODS

This study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression.

RESULTS

The mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01-1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls.

CONCLUSION

Our data suggest that higher levels of Hcy may be associated with an increased risk for MSA.

Authors+Show Affiliations

Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26291976

Citation

Zhang, Shuyu, et al. "Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: a Case-Control Study." PloS One, vol. 10, no. 8, 2015, pp. e0136468.
Zhang S, Shi C, Mao C, et al. Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. PLoS ONE. 2015;10(8):e0136468.
Zhang, S., Shi, C., Mao, C., Song, B., Hou, H., Wu, J., ... Xu, Y. (2015). Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. PloS One, 10(8), pp. e0136468. doi:10.1371/journal.pone.0136468.
Zhang S, et al. Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: a Case-Control Study. PLoS ONE. 2015;10(8):e0136468. PubMed PMID: 26291976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. AU - Zhang,Shuyu, AU - Shi,Changhe, AU - Mao,Chengyuan, AU - Song,Bo, AU - Hou,Haiman, AU - Wu,Jun, AU - Liu,Xinjing, AU - Luo,Haiyang, AU - Sun,Shilei, AU - Xu,Yuming, Y1 - 2015/08/20/ PY - 2015/03/24/received PY - 2015/08/03/accepted PY - 2015/8/21/entrez PY - 2015/8/21/pubmed PY - 2016/5/14/medline SP - e0136468 EP - e0136468 JF - PloS one JO - PLoS ONE VL - 10 IS - 8 N2 - BACKGROUND: Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine. METHODS: This study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression. RESULTS: The mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01-1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls. CONCLUSION: Our data suggest that higher levels of Hcy may be associated with an increased risk for MSA. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26291976/Plasma_Homocysteine_Vitamin_B12_and_Folate_Levels_in_Multiple_System_Atrophy:_A_Case_Control_Study_ L2 - http://dx.plos.org/10.1371/journal.pone.0136468 DB - PRIME DP - Unbound Medicine ER -